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Attaching biomolecules onto a CD scaffold is a known strategy to enhance their properties, but designing CD\u2010AHL conjugates has never been reported. These molecules were fully characterized by NMR and high\u2010resolution mass spectrometry, and the study of their solubility and conformation reveals significant conformational changes due to the presence of the AHL appendage on the CD structure. One of the hybrids (per\u2010AHL\u2010<jats:italic>\u03b2<\/jats:italic>\u2010CD, <jats:bold>9<\/jats:bold><jats:sub><jats:bold>B<\/jats:bold><\/jats:sub>) exhibits higher solubility in water than AHL and <jats:italic>\u03b2<\/jats:italic>\u2010CD alone. The new CD\u2010AHLs conjugates are found to modulate bioluminescence in a quorum Sensing LuxR\u2010regulated light\u2010producing bacterial model, with significant variations depending on the structure. The per\u2010AHL\u2010<jats:italic>\u03b2<\/jats:italic>\u2010CD, <jats:bold>9<\/jats:bold><jats:sub><jats:bold>B<\/jats:bold><jats:bold>,<\/jats:bold><\/jats:sub> is found to be the most active compound in the series.<\/jats:p>","DOI":"10.1002\/cbic.202500525","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T18:49:32Z","timestamp":1758134972000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects on LuxR\u2010Regulated Bioluminescence of Cyclodextrin\u2010Acyl\u2010L\u2010Homoserine Lactone Hybrids"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7596-6631","authenticated-orcid":false,"given":"Nicolas","family":"Tinet","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Picardie Jules Verne Laboratoire de Glycochimie et des Agro\u2010ressources d\u2019Amiens (UR 7378 LG2A)  33 rue Street Leu 80039 Amiens Cedex 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