{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T02:33:49Z","timestamp":1793759629237,"version":"4.6.1"},"reference-count":16,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2025,10,31]]},"abstract":"<jats:p>\n                    Tuberculosis, which the WHO describes as the \u201cworld's top infectious killer,\u201d demands novel combating strategies rather than conventional ones, as the situation of\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (Mtb) resistance to therapeutic drugs is continuous, leading to millions of deaths each year. In a recent study, Lai et al. report a manganese(I)\u2010based photoactivatable carbon monoxide\u2010releasing molecule (Mn\u2010PTP) that unifies photodynamic therapy, transition metal reactivity, and carbon monoxide (CO) delivery into a single light\u2010activated therapeutic platform. Upon white\u2010light irradiation, Mn\u2010PTP releases CO, generates both type I and type II reactive oxygen species (ROS), liberates a toxic antibacterial ligand (PTP), and forms catalytically active manganese oxides (MnO\n                    <jats:sub>x<\/jats:sub>\n                    ) species that decompose intracellular hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ), thereby alleviating hypoxia and amplifying ROS\u00a0generation. Mn\u2010PTP demonstrates high selectivity for\n                    <jats:italic>Mycobacterium smegmatis<\/jats:italic>\n                    with, potent in\u2009vitro antibacterial activity (MIC\n                    <jats:sub>90<\/jats:sub>\n                    \u2009=\u20093.11\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    M), robust biofilm disruption of\n                    <jats:italic>M. smegmatis<\/jats:italic>\n                    , and minimal cytotoxicity to normal cells. In in\u2009vivo, the compound significantly accelerates wound healing in infected mice, outperforming isoniazid. This highlight discusses Mn\u2010PTP as a powerful \u201cone\u2010for\u2010all\u201d agent which, upon irradiation, releases five key components that, much like the five fingers through coordinated action, form a fist that effectively combats and eliminates bacterial infections, offering a powerful blueprint for next\u2010generation metal\u2010based therapeutics against persistent mycobacterial infections.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202500529","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:27:37Z","timestamp":1759174057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Five\u2010In\u2010One Antibacterial Strategy: A Mn(I) Complex Lights Up the Fight Against Tuberculosis"],"prefix":"10.1002","volume":"26","author":[{"given":"Maryam","family":"Bashir","sequence":"first","affiliation":[{"name":"Department of Biosciences Jamia Millia Islamia  New Delhi 110025 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9175-198X","authenticated-orcid":false,"given":"Md Kausar","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Chemistry Haverford College  370 Lancaster Avenue Haverford Pennsylvania 19041 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(22)00359-7"},{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-023-00463-4"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202310040"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2dt12460b"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202423335"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202112236"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00609F"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202100469"},{"key":"e_1_2_3_5_3","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c12254"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-024-01049-x"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC05326A"},{"key":"e_1_2_3_6_3","doi-asserted-by":"publisher","DOI":"10.1039\/C9SC06460E"},{"key":"e_1_2_3_6_4","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c16035"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202217345"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2023.116778"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c05490"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202500529","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbic.202500529","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.202500529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:28:17Z","timestamp":1777404497000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.202500529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":16,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2025,10,31]]}},"alternative-id":["10.1002\/cbic.202500529"],"URL":"https:\/\/doi.org\/10.1002\/cbic.202500529","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"2025-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500529"}}