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The first\u2010line treatment for IDA is oral iron supplementation, preferred for its cost\u2010effectiveness and convenience of administration but is often accompanied by side effects like oxidative stress, infections, and low\u2010solubility\/precipitation. This study explores the use of ferritins\u2014self\u2010assembled nanocage proteins serving as soluble cellular\u2010iron reservoirs\u2014as a safer alternative for oral iron intervention. Ideal oral iron supplements must withstand gastric conditions, not trigger oxidative stress, and reach the absorption site intact. DNA protection assays and microbial growth studies demonstrate the antioxidative properties of ferritin, contrary to ferrous salts, underscoring its potential as a safer iron supplement. While ferritin shows commendable gastric tolerance, prolonged exposure can hamper its structural integrity\/mineral retention. To further enhance its stability, ferritin is fabricated with gelatins, which preserved its structure\/iron content under simulated gastric conditions. The combination of inherent antioxidant and controlled iron release properties of ferritin with gelatin's protective effect could help overcome the limitations of the commercial supplements. The findings of this study could pave the way for the development of \"gelatin\u2010coated iron\u2010loaded ferritin\"\u2010based oral formulations as a safer option for IDA management.<\/jats:p>","DOI":"10.1002\/cbic.202500620","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:16:20Z","timestamp":1760404580000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Improving the Gastric Resilience of Ferritin Nanocages by Fabrication with Gelatin for the Development of Oral Iron Supplements"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4367-5847","authenticated-orcid":false,"given":"Rohit Kumar","family":"Raut","sequence":"first","affiliation":[{"name":"Department of Chemistry National Institute of Technology  Rourkela Odisha 769008 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8890-2521","authenticated-orcid":false,"given":"Gargee","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Institute of Technology  Rourkela Odisha 769008 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2483-1047","authenticated-orcid":false,"given":"Swagatika","family":"Mallik","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Institute of Technology  Rourkela Odisha 769008 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2849-3292","authenticated-orcid":false,"given":"Rabindra K.","family":"Behera","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Institute of Technology  Rourkela Odisha 769008 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"46","volume-title":"Accelerating Anaemia Reduction: A Comprehensive Framework for Action","author":"WHO","year":"2023"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-05-815944"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60865-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar0302336"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2011.08.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb300323q"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118925645.ch2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2020.100861"},{"key":"e_1_2_8_10_1","first-page":"82","volume-title":"WHO Guideline on use of Ferritin Concentrations to Assess Iron Status in Individuals and Populations","author":"WHO","year":"2020"},{"key":"e_1_2_8_11_1","first-page":"79","volume-title":"Guideline on Haemoglobin Cutoffs to Define Anaemia in Individuals and Populations","author":"WHO","year":"2024"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2020000132"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i35.7908"},{"key":"e_1_2_8_14_1","first-page":"241","volume":"11","author":"Jimenez K.","year":"2015","journal-title":"Gastroenterol. 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