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This review systematically discusses the recent advances in the development of RPhs, focusing on state\u2010of\u2010the\u2010art probe design strategies and click chemistry applications that accelerate RPh syntheses and improve targeting efficiency. The manuscript synthesizes literature from multiple databases spanning January 2014 to April 2025, encompassing diagnostic modalities including positron emission tomography (PET) and single\u2010photon emission computed tomography (SPECT) imaging, and therapeutic applications utilizing alpha and beta emitters such as\n                    <jats:sup>225<\/jats:sup>\n                    Ac and\n                    <jats:sup>177<\/jats:sup>\n                    Lu. 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