{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:52:53Z","timestamp":1777945973220,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["20020190100226BA"],"award-info":[{"award-number":["20020190100226BA"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2025,12,11]]},"abstract":"<jats:p>\n                    <jats:italic>Trypanosoma cruzi<\/jats:italic>\n                    , the etiologic agent of Chagas disease, is a protozoan parasite transmitted to humans via the feces of blood\u2010sucking triatomine vectors such as\n                    <jats:italic>Triatoma infestans.<\/jats:italic>\n                    It has been shown that galactofuranose\u2010containing oligosaccharides present in mucins of\n                    <jats:italic>T. cruzi<\/jats:italic>\n                    are involved in parasite adhesion to the\n                    <jats:italic>T. infestans<\/jats:italic>\n                    rectal ampoule, a key step in the differentiation programme from dividing epimastigote to nondividing mammal\u2010infective metacyclic forms of the parasite. To further characterize this process, the \u03b1\u2010benzyl glycoside of \u03b2\u2010D\u2010Gal\n                    <jats:italic>f<\/jats:italic>\n                    (1\u2009\u2192\u20092)\u2010\u03b2\u2010D\u2010Gal\n                    <jats:italic>f<\/jats:italic>\n                    (1\u2009\u2192\u20094)\u2010[\u03b2\u2010D\u2010Gal\n                    <jats:italic>p<\/jats:italic>\n                    \u2010(1\u2009\u2192\u20096)]\u2010D\u2010GlcNAc is synthesized and its alditol derivative is spectroscopically characterized. The tetrasaccharide component of this glycoside is a substructure of the\n                    <jats:italic>O<\/jats:italic>\n                    \u2010linked pentasaccharide and hexasaccharide structures found in the\n                    <jats:italic>T. cruzi<\/jats:italic>\n                    epimastigote mucins. The tetrasaccharide glycoside inhibits parasite adhesion to the rectal ampoule of\n                    <jats:italic>T. infestans<\/jats:italic>\n                    , suggesting that some or all of the binding capacity of\n                    <jats:italic>T. cruzi<\/jats:italic>\n                    epimastigotes resides within this\n                    <jats:italic>O<\/jats:italic>\n                    \u2010glycan tetrasaccharide substructure. Since\n                    <jats:italic>T. cruzi<\/jats:italic>\n                    mucin\n                    <jats:italic>O<\/jats:italic>\n                    \u2010linked glycans are known to be acceptors for\n                    <jats:italic>T. cruzi<\/jats:italic>\n                    trans\u2010sialidase, it is investigated whether the tetrasaccharide substructure acts as an acceptor substrate for this activity. The successful transfer of sialic acid to the tetrasaccharide glycoside indicates that further elaboration to the pentasaccharide and hexasaccharide structures is not essential for sialic acid transfer.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202500693","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T12:21:13Z","timestamp":1762518073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Tetrasaccharide Containing a Galactofuranosyl Determinant of Mucins from\n                    <i>Trypanosoma cruzi<\/i>\n                    Inhibits the Parasite Adhesion on\n                    <i>Triatoma infestans<\/i>\n                    Rectum"],"prefix":"10.1002","volume":"26","author":[{"given":"Carmen R.","family":"Cori","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Pab. 2, Piso 3, Ciudad Universitaria  Buenos Aires 1428 Argentina"},{"name":"CONICET\u2010Universidad de Buenos Aires Centro de Investigaciones en Hidratos de Carbono (CIHIDECAR) Pab. 2, Piso 3, Ciudad Universitaria  Buenos Aires 1428 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lautaro","family":"Altaleff","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Pab. 2, Piso 3, Ciudad Universitaria  Buenos Aires 1428 Argentina"},{"name":"CONICET\u2010Universidad de Buenos Aires Centro de Investigaciones en Hidratos de Carbono (CIHIDECAR) Pab. 2, Piso 3, Ciudad Universitaria  Buenos Aires 1428 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosal\u00eda","family":"Agust\u00ed","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Pab. 2, Piso 3, Ciudad Universitaria  Buenos Aires 1428 Argentina"},{"name":"CONICET\u2010Universidad de Buenos Aires Centro de Investigaciones en Hidratos de Carbono (CIHIDECAR) Pab. 2, Piso 3, Ciudad Universitaria  Buenos Aires 1428 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda de los Milagros","family":"C\u00e1mara","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas (IIBio) Campus UNSAM Universidad Nacional de San Mart\u00edn (UNSAM\u2010CONICET)  Avenue 25 de Mayo y Francia San Mart\u00edn B1650HMP Buenos Aires Argentina"},{"name":"Escuela de Bio y Nanotecnolog\u00edas (EByN) UNSAM  Buenos Aires 1428 Argentina"},{"name":"Universidad Argentina de la Empresa (UADE) Instituto de Tecnolog\u00eda (INTEC)  Buenos Aires C1428EGA Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos A.","family":"Buscaglia","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biotecnol\u00f3gicas (IIBio) Campus UNSAM Universidad Nacional de San Mart\u00edn (UNSAM\u2010CONICET)  Avenue 25 de Mayo y Francia San Mart\u00edn B1650HMP Buenos Aires Argentina"},{"name":"Escuela de Bio y Nanotecnolog\u00edas (EByN) UNSAM  Buenos Aires 1428 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa M.","family":"de Lederkremer","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires Pab. 2, Piso 3, Ciudad Universitaria  Buenos Aires 1428 Argentina"},{"name":"CONICET\u2010Universidad de Buenos Aires Centro de Investigaciones en Hidratos de Carbono (CIHIDECAR) Pab. 2, Piso 3, Ciudad Universitaria  Buenos Aires 1428 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