{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:41:06Z","timestamp":1777891266205,"version":"3.51.4"},"reference-count":77,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    Skin burns are a major health concern that is caused by severe electric shocks, chemical and thermal exposure. The intense skin burns can cause the fibroblast cell death which can lead to the delayed wound healing. Direct ink write (DIW) printing is a promising three\u2010dimensional (3D) printing technology that provides availability of different polymeric solutions and incorporation of bioactive agents within the polymeric blends with low material wastage. Herein, we fabricated a promising combination of ink consisting of sodium alginate (Na\u2010ALG), guar gum (GG), and\n                    <jats:italic>Ficus carica<\/jats:italic>\n                    (FC) for DIW printing. The formulated scaffolds showed favorable rheological properties and layer fidelity. The scaffolds depicted appropriate intercrosslinked porous morphology that supported swelling ability. Na\u2010ALG\/GG\/FC scaffolds were biodegradable, released gallic acid (GA) and demonstrated antibacterial efficacy against\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    . Scaffold exhibited biocompatibility of 109% on Day 7 with fibroblasts and released vascular endothelial growth factor (VEGF) which indicated formation of new blood vessels. Hence, Na\u2010ALG\/GG\/FC scaffolds are a potential candidate for treating chronic wounds.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202500875","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:59:23Z","timestamp":1777373963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Ficus carica<\/i>\n                    Extract Loaded 3D\u2010Printed Sodium Alginate\/Guar Gum Scaffolds for Potential Wound Healing Applications: An In Vitro Study"],"prefix":"10.1002","volume":"27","author":[{"given":"Aima","family":"Ghouri","sequence":"first","affiliation":[{"name":"Bioengineering Research and Development Private Limited  Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5201-973X","authenticated-orcid":false,"given":"Muhammad Atiq","family":"Ur Rehman","sequence":"additional","affiliation":[{"name":"Bioengineering Research and Development Private Limited  Islamabad Pakistan"},{"name":"Department of Materials Science &amp; Engineering Institute of Space Technology  Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizwan Ahmed","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering College of Engineering Prince Sattam bin Abdulaziz University  Al-kharj Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussein","family":"Alrobei","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering College of Engineering Prince Sattam bin Abdulaziz University  Al-kharj Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"132824","DOI":"10.1016\/j.ijbiomac.2024.132824","article-title":"Development and Characterization of Polyethylene Oxide and Guar Gum-Based Hydrogel; a Detailed in-Vitro Analysis of Degradation and Drug Release Kinetics","volume":"273","author":"Aizaz A.","year":"2024","journal-title":"International Journal of Biological Macromolecules"},{"issue":"6","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1524-4725.2009.01153.x","article-title":"Biologic Dressings: Current Applications and Limitations in Dermatologic Surgery","volume":"35","author":"Chern P. 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