{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:51:39Z","timestamp":1773885099098,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2026,2,12]]},"abstract":"<jats:p>\n                    The CH\u2010oxidative activity of\n                    <jats:italic>Wolfiporia cocos<\/jats:italic>\n                    cultures of different ages was studied utilizing diamondoid derivatives as conformationally rigid models. Adamantane\u20101\u2010ol and 1\u2010bromoadamantane, traditional precursors for the synthesis of polysubstituted adamantanes, gave qualitatively similar reaction mixtures in which adamantane diols dominated. While the reactions occurred with high preparative yields, the biotransformation does not display clear differences from classic electrophilic or radical adamantane functionalization reactions. In contrast, the fungal oxidation of diamantane\u20104\u2010ol occurred with unexpected selectivity yielding diamantane\u20104,9\u2010diol and diamantane\u20101,9\u2010diol. The latter product is quite uncharacteristic for diamantane chemistry because the most deactivated CH\u2010position is attacked. To elucidate the active fungal component, additional experiments were performed with supernatant and resting cells harvested at various culture ages. Oxidative activity was detected in resting cells from 4\u2010 and 6\u2010day\u2010old cultures in pure water medium, and from 6\u2010day\u2010old cultures in buffer at pH 2, but disappeared at higher pH values.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202500930","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T06:28:21Z","timestamp":1770013701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biocatalytic Synthesis of Diamondoid Diols by the Brown\u2010Rot Fungus\n                    <i>Wolfiporia cocos<\/i>"],"prefix":"10.1002","volume":"27","author":[{"given":"Valeriia V.","family":"Nikitenkova","sequence":"first","affiliation":[{"name":"Institute of Food Chemistry and Food Biotechnology Justus Liebig University Giessen  Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aryna M.","family":"Sydorenko","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Technology Igor Sikorsky Kyiv Polytechnic Institute  Kyiv Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Zorn","sequence":"additional","affiliation":[{"name":"Institute of Food Chemistry and Food Biotechnology Justus Liebig University Giessen  Giessen Germany"},{"name":"Fraunhofer Institute for Molecular Biology and Applied Ecology  Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5184-704X","authenticated-orcid":false,"given":"Tatyana","family":"Zhuk","sequence":"additional","affiliation":[{"name":"Institute of Food Chemistry and Food Biotechnology Justus Liebig University Giessen  Giessen Germany"},{"name":"Faculty of Chemical Technology Igor Sikorsky Kyiv Polytechnic Institute  Kyiv Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200701684"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117592"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.3c00427"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2021.127882"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22081265"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo702310g"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.132167"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2018.03.011"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA06402B"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orggeochem.2018.11.010"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.0c01060"},{"key":"e_1_2_10_13_1","unstructured":"T.Takebe T.Ota H.Obata andH.Hiroyuki WO 2006051803 A1 (2005)."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2012.02.033"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA10887J"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201400601"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c01058"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CE00775H"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2019.130576"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2013.11.010"},{"key":"e_1_2_10_21_1","unstructured":"W.Nan Z.Hong andY.Youguo CN. 112159304\u2009A (2021)."},{"key":"e_1_2_10_22_1","unstructured":"W.Nan Z.Hong andY.Youguo CN. 112250578\u2009A (2021)."},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-386540-3.00014-9"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-005-0167-7"},{"key":"e_1_2_10_25_1","first-page":"1833","article-title":"Selcetive Biohydroxylation of 1\u2010Substituted Adamantanes Using Absidia Cylindrospora (I.M.I. 342950)","author":"Bailey P. 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