{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:31:48Z","timestamp":1792603908241,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2026,4,14]]},"abstract":"\n This paper presents the design and synthesis of a new rhodamine\u2010based Schiff base chemosensor (\n L<\/jats:bold>\n ) with exceptional selectivity and sensitivity for Cd\n 2+<\/jats:sup>\n . An analysis of\n L<\/jats:bold>\n was conducted using various spectroscopic techniques, thereby validating its structure and activity. The chemosensor exhibited a clear turn\u2010on fluorescence response and significant colour change with Cd\n 2+<\/jats:sup>\n ions in acetonitrile. Binding investigations confirmed that\n L<\/jats:bold>\n interacts with Cd\n 2+<\/jats:sup>\n ions in a 1:1 ratio, as shown by Job's plot and Benesi\u2010Hildebrand (B\u2010H) analysis. The binding constant (\n K<\/jats:italic>\n a<\/jats:sub>\n \u2009=\u20090.107 \u00d7 10\n 4<\/jats:sup>\n ) highlights the strong and specific interactions between\n L<\/jats:bold>\n and Cd\n 2+<\/jats:sup>\n ions.The limit of detection was found to be (LOD\u2009=\u20092.01\u2009nM) for Cd\n 2+<\/jats:sup>\n ions. DFT studies confirmed the stability of the\n L<\/jats:bold>\n \u2010Cd\n 2+<\/jats:sup>\n complex, indicating the coordination of Cd\n 2+<\/jats:sup>\n to the four atoms in\n L<\/jats:bold>\n . The reversible properties of\n L<\/jats:bold>\n in the presence of EDTA illustrate its potential as a reusable chemosensor and emphasise its INHIBIT molecular logic gate functionality. Molecular docking analyses of\n L<\/jats:bold>\n with the human DNA\u2010binding protein 5VBN were performed to assess its binding affinity and interaction characteristics. The practical application was demonstrated by the effective detection of Cd\n 2+<\/jats:sup>\n in actual water, vegetable and fruit juice samples, solid\u2010state sensing tests and filter paper\u2010based assays, highlighting its potential for environmental monitoring.\n <\/jats:p>","DOI":"10.1002\/cbic.202500975","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T09:36:17Z","timestamp":1776072977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Development of a Rhodamine\u2010Based Chemosensor for Cd\n 2+<\/sup>\n Ions: A Combined Approach of Colorimetric, Fluorescent Detection, and Computational Modelling"],"prefix":"10.1002","volume":"27","author":[{"given":"Ram","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Delhi Delhi India"},{"name":"Department of Chemistry Bhaskaracharya College of Applied Sciences University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Takkar","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry Bhagwan Parshuram Institute of Technology Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5029-317X","authenticated-orcid":false,"given":"Bholey","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Swami Shraddhanand College University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Kakkar","sequence":"additional","affiliation":[{"name":"Computational Chemistry Group Department of Chemistry University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parveen","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Botany Swami Shraddhanand College University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balaram","family":"Pani","sequence":"additional","affiliation":[{"name":"Department of Chemistry Bhaskaracharya College of Applied Sciences University of Delhi Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.128894"},{"key":"e_1_2_10_3_1","volume-title":"The Roles of Iron and Cadmium in Human Health","author":"Wang Y.","year":"2014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-021-02827-7"},{"key":"e_1_2_10_5_1","first-page":"1","article-title":"Induction of Enzymatic and Non\u2010enzymatic Antioxidants In Response to Cd2+ Stress In a Cyanobacterium","volume":"7","author":"Sachu M.","year":"2021","journal-title":"RJLBPCS"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/su141610320"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2211-2692"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.9734\/bpi\/cerb\/v2\/17514D"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2024.1327611"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408347.2024.2339968"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1CS15245A"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10853-020-05544-z"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.135859"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5NJ01755F"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5AY00482A"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/bios13060612"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4RA03097D"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2017.04.046"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202401510"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/M955"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10895-017-2046-x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.77.3865"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.458452"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/P29930000799"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00549096"},{"key":"e_1_2_10_26_1","doi-asserted-by":"crossref","unstructured":"M. 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