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This renders them promising molecular targets for radiotracer development. In this study, isomeric\n                    <jats:italic>closo<\/jats:italic>\n                    \u2010dicarbadodecaborane(12)\u2010based dual COX\u20102\/5\u2010LO inhibitors (\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    ) served as scaffolds for iodine\u2010123\u2010labeling. Iodinated derivatives\n                    <jats:bold>3<\/jats:bold>\n                    and\n                    <jats:bold>4<\/jats:bold>\n                    inhibited 5\u2010LO more potently than COX\u20102 in vitro (\n                    <jats:italic>IC<\/jats:italic>\n                    <jats:sub>50<\/jats:sub>\n                    0.62 \u00b5M and 41.3 \u00b5M (\n                    <jats:bold>3<\/jats:bold>\n                    ); 0.54 \u00b5M and 67.7 \u00b5M (\n                    <jats:bold>4<\/jats:bold>\n                    )). Radioiodination yielded 39%\u201371% of\n                    <jats:bold>[<\/jats:bold>\n                    <jats:sup>\n                      <jats:bold>123<\/jats:bold>\n                    <\/jats:sup>\n                    <jats:bold>I]3<\/jats:bold>\n                    and\n                    <jats:bold>[<\/jats:bold>\n                    <jats:sup>\n                      <jats:bold>123<\/jats:bold>\n                    <\/jats:sup>\n                    <jats:bold>I]4<\/jats:bold>\n                    ; and the formulations were stabilized with antioxidants. Cellular uptake of\n                    <jats:bold>[<\/jats:bold>\n                    <jats:sup>\n                      <jats:bold>123<\/jats:bold>\n                    <\/jats:sup>\n                    <jats:bold>I]3<\/jats:bold>\n                    and\n                    <jats:bold>[<\/jats:bold>\n                    <jats:sup>\n                      <jats:bold>123<\/jats:bold>\n                    <\/jats:sup>\n                    <jats:bold>I]4<\/jats:bold>\n                    was evaluated in human cells with distinct COX\u20102 and 5\u2010LO expression: U87 glioblastoma, HT\u201029 colorectal carcinoma cells, THP\u20101 monocytes (MC) and macrophages. Consistent with the observed inhibitory potency, the uptake of the radiotracers proved to be independent of COX\u20102 expression. In contrast, it was influenced by 5\u2010LO expression in tumor but not inflammatory cells. Single\u2010photon emission computed tomography imaging in tumor xenograft mouse models revealed no tumor retention of\n                    <jats:bold>[<\/jats:bold>\n                    <jats:sup>\n                      <jats:bold>123<\/jats:bold>\n                    <\/jats:sup>\n                    <jats:bold>I]3<\/jats:bold>\n                    and\n                    <jats:bold>[<\/jats:bold>\n                    <jats:sup>\n                      <jats:bold>123<\/jats:bold>\n                    <\/jats:sup>\n                    <jats:bold>I]4<\/jats:bold>\n                    due to rapid metabolism via radiodeiodination. Despite successful radiosynthesis and in vitro evaluation of iodine\u2010123\u2010labeled COX\u20102\/5\u2010LO inhibitors, improved inhibitory activity and stability are required for development of suitable radiotracers.\n                  <\/jats:p>","DOI":"10.1002\/cbic.202600004","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T05:24:31Z","timestamp":1775021071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Radioiodination of Two Carborane\u2010Based Dual Cyclooxygenase\u20102\/5\u2010Lipoxygenase Inhibitors and Their In Vitro and In Vivo Evaluation"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4550-0394","authenticated-orcid":false,"given":"Jonas","family":"Sch\u00e4dlich","sequence":"first","affiliation":[{"name":"Institute of Radiopharmaceutical Cancer Research Helmholtz\u2010Zentrum Dresden\u2010Rossendorf  Dresden 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