{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:40:46Z","timestamp":1777891246843,"version":"3.51.4"},"reference-count":75,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    Herein, we have synthesized the commonly known protonated 5,10,15,20\u2010tetrakis(4\u2010pyridyl)porphyrin (compound\n                    <jats:bold>1<\/jats:bold>\n                    ) and a mixed\u2010linker zinc\u2010based metal\u2013organic framework (compound\n                    <jats:bold>2<\/jats:bold>\n                    ) and evaluated their antibacterial photodynamic therapy. The crystal structure of\n                    <jats:bold>1<\/jats:bold>\n                    exhibits hydrogen\u2010bonded scaffolds and engages in \u03c0\u2010stacking interactions, whereas compound\n                    <jats:bold>2<\/jats:bold>\n                    is coordinated through zinc metal nodes to porphyrin and terephthalate ions, forming an interpenetrated 3D framework with a\n                    <jats:bold>mog<\/jats:bold>\n                    topology. In\n                    <jats:bold>2<\/jats:bold>\n                    , we observed a high theoretical surface area of 2915\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    g\n                    <jats:sup>\u22121<\/jats:sup>\n                    calculated using a N\n                    <jats:sub>2<\/jats:sub>\n                    apparatus. Molecular orbital calculations confirm that the highest occupied and lowest unoccupied molecular orbitals are mainly localized on the porphyrin core, with the terephthalate linker acting as an electronic spacer. Finally,\n                    <jats:bold>2<\/jats:bold>\n                    exhibits an enhanced reactive oxygen species production and superior antibacterial activity compared to\n                    <jats:bold>1<\/jats:bold>\n                    under irradiation with red light. These performances clearly resulted in inhibition zones of 28\u00b11\u2009mm (MRSA) and 21\u00b11\u2009mm (\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ) and strong binding properties to the proteins. These findings demonstrate that\n                    <jats:bold>2<\/jats:bold>\n                    functions as a robust, light\u2010activated antibacterial platform and provide a rational route for next\u2010generation antibacterial agents.\n                  <\/jats:p>","DOI":"10.1002\/cbic.70286","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:30:14Z","timestamp":1776450614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zinc\u2013Porphyrin Terephthalate\u2010Based Metal\u2013Organic Framework: Structural Insights and Functional Antibacterial Properties"],"prefix":"10.1002","volume":"27","author":[{"given":"Kumar","family":"Shivam","sequence":"first","affiliation":[{"name":"Amity Institute of Click Chemistry Research and Studies Amity University Uttar Pradesh  Noida Uttar Pradesh 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