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Genetic impacts of these diseases were probed by extracting DNA from selected muscle tissues of either a mouse model of X chromosome\u2010linked muscular dystrophy (mdx, DMD model) or a heterozygous col5a1 (+\/\u2010) mouse (EDS model). Complementary square wave voltammetry (SWV) and liquid chromatography\u2010tandem mass spectrometry (LC\u2010MS\/MS) approaches were used to assess extracted DNA. SWV analysis was performed by immobilizing DNA layer\u2010by\u2010layer (LbL) on pyrolytic graphite (PG) electrodes before oxidation in the presence of Ru(bpy)\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>2+<\/jats:sup>\n                    . Changes in SWV peak currents (I\n                    <jats:sub>p<\/jats:sub>\n                    ) at \u223c+1.05\u2009V vs. SCE indicated significant DNA alterations in the genetically altered mouse tissues compared to wild type (WT) controls. Both mdx and heterozygous col5a1(+\/\u2010) samples exhibited statistically significant decreased I\n                    <jats:sub>p<\/jats:sub>\n                    levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) compared to WT DNA suggesting guanine content varied due to the genetic alterations, which was statistically more significant in leg muscle DNA. MS\/MS validated and expanded on the SWV results. DNA base analysis showed increased oxidative damage alongside changes in undamaged base content in mdx mice. DNA from col5a1(+\/\u2010) leg muscles exhibited significant changes to undamaged base content, showcasing similar trends.\n                  <\/jats:p>","DOI":"10.1002\/cbic.70368","type":"journal-article","created":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T18:31:32Z","timestamp":1778437892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of DNA Variations From Two In Vivo Skeletal Muscle Disorder Mouse Models Using Complementary Square\u2010Wave Voltammetry and LC\u2010MS\/MS Analysis"],"prefix":"10.1002","volume":"27","author":[{"given":"Elizabeth R.","family":"LaFave","sequence":"first","affiliation":[{"name":"Department of Chemistry East Carolina University  Greenville North Carolina U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grayson B.","family":"Sink","sequence":"additional","affiliation":[{"name":"Department of Chemistry East Carolina University  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