{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:00:13Z","timestamp":1792324813726,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2026,5,14]]},"abstract":"<jats:p>\n                    Hydrazone\u2010based ligands constitute multifunctional pharmacophores owing to their flexible coordination modes and tunable electronic properties. Upon metal complexation, these features modulate physicochemical characteristics and biological responses, enabling the development of metal\u2010based therapeutics. This study reports the rational design, synthesis, structural characterization, and anti\u2010inflammatory evaluation of a series of hydrazone ligands and their Cu(II) and Zn(II) complexes. Spectroscopic and crystallographic analyses confirmed tridentate coordination through azomethine nitrogen and carbonyl oxygen donors, leading to distorted octahedral geometries around the metal centers. In\u2009vitro cyclooxygenase inhibition assays showed that metal coordination significantly enhanced anti\u2010inflammatory activity relative to the free ligands. The Cu(II) complexes [Cu(acbh)\n                    <jats:sub>2<\/jats:sub>\n                    ] (\n                    <jats:bold>3<\/jats:bold>\n                    ) and [Cu(bcbh)\n                    <jats:sub>2<\/jats:sub>\n                    ] (\n                    <jats:bold>5<\/jats:bold>\n                    ), along with the Zn(II) complex [Zn(bcbh)\n                    <jats:sub>2<\/jats:sub>\n                    ] (\n                    <jats:bold>6<\/jats:bold>\n                    ), exhibited notable COX\u20102 selectivity compared to the reference drug celecoxib. Among all compounds, complex\n                    <jats:bold>6<\/jats:bold>\n                    emerged as the most potent dual COX\u20101\/COX\u20102 inhibitor, displaying a COX\u20102 IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 0.41\u2009\u00b5M and a selectivity index of 307.32, indicating potential as a broad\u2010spectrum anti\u2010inflammatory agent. Molecular docking studies supported these results, revealing favorable binding energies and stable interactions of the metal complexes within COX active sites. Overall, these findings emphasize the role of metal coordination in enhancing enzyme binding and biological activity.\n                  <\/jats:p>","DOI":"10.1002\/cbic.70374","type":"journal-article","created":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T18:41:14Z","timestamp":1778438474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["From Structure to Function: COX\u2010Selective Anti\u2010Inflammatory Activity of Cu(II) and Zn(II) Hydrazone Complexes"],"prefix":"10.1002","volume":"27","author":[{"given":"Ram Nayan","family":"Gautam","sequence":"first","affiliation":[{"name":"Department of Chemistry Banaras Hindu University  Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riya","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Chemistry Banaras Hindu University  Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diptee","family":"Mitra","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Lucknow  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Maharaja Agrasen School of Pharmacy Maharaja Agrasen University  Solan Himachal Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupam","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry Banaras Hindu University  Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Lucknow  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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