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This method was used to synthesize a series of six novel examples of (\u00b1)\u20107\u2010amino\u20106\u2010aryl\u20106\n                    <jats:italic>H<\/jats:italic>\n                    \u2010chromeno[4,3\u2010\n                    <jats:italic>b<\/jats:italic>\n                    ]quinolines (\n                    <jats:bold>3<\/jats:bold>\n                    ), which were designed as potential cholinesterase inhibitors. Subsequently, the new chromeno[4,3\u2010\n                    <jats:italic>b<\/jats:italic>\n                    ]quinolines were evaluated for their AChE and BChE inhibitory activity and subjected to molecular docking studies. In vitro cholinesterase assays and in silico docking demonstrated that all newly modified tacrine analogs\n                    <jats:bold>3<\/jats:bold>\n                    exhibited higher\n                    <jats:italic>Hs<\/jats:italic>\n                    BChE inhibitory activity compared to\n                    <jats:italic>Hs<\/jats:italic>\n                    AChE. Specifically, the most effective human cholinesterase inhibitor was the compound (\u00b1)\u20107\u2010amino\u20106\u2010phenyl\u20106\n                    <jats:italic>H<\/jats:italic>\n                    \u2010chromeno[4,3\u2010\n                    <jats:italic>b<\/jats:italic>\n                    ]quinoline (\n                    <jats:bold>3aa<\/jats:bold>\n                    ), with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 2.73\u2009\u03bcM for\n                    <jats:italic>Hs<\/jats:italic>\n                    AChE and 0.096\u2009\u03bcM for\n                    <jats:italic>Hs<\/jats:italic>\n                    BChE. These findings suggest that compound\n                    <jats:bold>3aa<\/jats:bold>\n                    is a promising candidate for further assessment in synthetic Alzheimer's disease models.\n                  <\/jats:p>","DOI":"10.1002\/cbic.70391","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:46:33Z","timestamp":1779695193000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Promising Flavonoid\u2010Fused Aminoquinolines as Synthetic Alzheimer's Disease Models: Design, Synthesis, Anticholinesterase Activity, ADMET and Molecular Docking"],"prefix":"10.1002","volume":"27","author":[{"given":"Inai\u00e1 O.","family":"Rocha","sequence":"first","affiliation":[{"name":"N\u00facleo de Qu\u00edmica de Heterociclos (NUQUIMHE) Department of Chemistry Federal University of Santa Maria  Santa Maria Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e1ssia P.","family":"Delgado","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Federal University of Santa Maria  Santa Maria Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo A.","family":"Nogara","sequence":"additional","affiliation":[{"name":"Federal Institute of Southern Rio Grande do Sul (IFSul)  Bag\u00e9 Rio Grande do Sul Brazil"},{"name":"Biological Science Graduate Program: Toxicological Biochemistry Federal University of Santa Maria  Santa Maria Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o B. T.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Federal University of Santa Maria  Santa Maria Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos A. P.","family":"Martins","sequence":"additional","affiliation":[{"name":"N\u00facleo de Qu\u00edmica de Heterociclos (NUQUIMHE) Department of Chemistry Federal University of Santa Maria  Santa Maria Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilo","family":"Zanatta","sequence":"additional","affiliation":[{"name":"N\u00facleo de Qu\u00edmica de Heterociclos (NUQUIMHE) Department of Chemistry Federal University of Santa Maria  Santa Maria Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2745-2061","authenticated-orcid":false,"given":"Helio G.","family":"Bonacorso","sequence":"additional","affiliation":[{"name":"N\u00facleo de Qu\u00edmica de Heterociclos (NUQUIMHE) Department of Chemistry Federal University of Santa Maria  Santa Maria Rio Grande do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1385272825666210716154531"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.10.060"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/18715273113126660166"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210\u2010199402040\u201000007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1210139"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.07.053"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm201460y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.10.039"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2015.11.008"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.133485"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.106704"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2025.145232"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2016.41"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2017.08.004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/74.4.418"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/162750"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10870\u2010018\u20100706\u20106"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2018.04.019"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.104649"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397911.2011.621096"},{"key":"e_1_2_9_22_1","first-page":"385","article-title":"Synthesis, Characterization and Biological Evaluation of 2\u2010Aryl\u20104\u2010phenyl\u20102H\u2010chromene\u20103\u2010benzimadazoles","volume":"7","author":"Kumar K. 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