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Reaction rate constants with\n                    <jats:italic>t<\/jats:italic>\n                    \u2010BuOO\n                    <jats:sup>\u2022<\/jats:sup>\n                    radicals were estimated by EPR, while their oxidation potentials were measured by square\u2010wave voltammetry. All derivatives exhibited significant radical quenching activity. The reactivity is depended on the nature and number of substituents, modulating the electron density and steric effects. The high activity with high rate constants is attributed to the formation of a Se\u2010centered conjugated dipolar transition state, where electron\u2010donating substituents were found to enhance the radical quenching efficiency. Additionally,\n                    <jats:italic>in silico<\/jats:italic>\n                    studies revealed that all compounds exhibited favorable binding affinities toward the histone deacetylase 8 protein.\n                  <\/jats:p>","DOI":"10.1002\/cbic.70437","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:45:21Z","timestamp":1783331121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Revisiting the Radical Quenching Activity of Ebselen Analogues in Homogeneous Phase and In Silico Anti\u2010ferroptotic Activity with Histone Deacetylase"],"prefix":"10.1002","volume":"27","author":[{"given":"Makich","family":"Musaelyan","sequence":"first","affiliation":[{"name":"A.B. 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