{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:14:38Z","timestamp":1784034878842,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CHE\u20102316599"],"award-info":[{"award-number":["CHE\u20102316599"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM145539"],"award-info":[{"award-number":["GM145539"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2026,7,14]]},"abstract":"<jats:p>\n                    <jats:italic>Streptococcus constellatus<\/jats:italic>\n                    inhabits the healthy human gastrointestinal tract and oral microbiome; however, the incidence of this species becoming opportunistically pathogenic has increased in recent decades.\n                    <jats:italic>S. constellatus<\/jats:italic>\n                    has the potential to cause severe pyogenic infections requiring combination antibiotic therapy or surgical intervention. Some virulence processes in\n                    <jats:italic>S. constellatus<\/jats:italic>\n                    , such as genetic competence, are regulated through quorum sensing (QS), facilitated by its 16\u2010mer competence stimulating peptide (CSP). Several target residues on the CSP molecule were identified that can be mutated to enhance the peptide activity and\/or lead to competitive inhibition of the competence regulon QS circuitry, thereby modulating related pathogenic phenotypes. Using a rational design approach, second\u2010generation peptide analog libraries were designed and screened, resulting in optimization of a competitive QS inhibitor, CSP\u2010D1AI4AM6A, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 38.3\u2009nM. Overall, this work provides a rational framework upon which novel QS modulators can be designed to attenuate virulence processes in this opportunistic pathogen.\n                  <\/jats:p>","DOI":"10.1002\/cbic.70444","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:16:02Z","timestamp":1782818162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of Quorum Sensing Modulators of\n                    <i>Streptococcus constellatus<\/i>"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5642-4246","authenticated-orcid":false,"given":"Keely M.","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Nevada, Reno  Reno Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel N.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Nevada, Reno  Reno Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella R.","family":"Lemieux","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Nevada, Reno  Reno Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar S.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Nevada, Reno  Reno Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yftah","family":"Tal\u2010Gan","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Nevada, Reno  Reno Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.956677"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2023.467"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000002062"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2013.4816"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1768655"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1678-9946202365010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/10962964251371493"},{"key":"e_1_2_8_9_1","first-page":"e87768","article-title":"Abscess from Dental Bacteria: A Case Report","volume":"17","author":"Staniszewska M.","year":"2025","journal-title":"Cureus"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2025.e02373"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2019.05.004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00995-13"},{"key":"e_1_2_8_13_1","first-page":"e14534","article-title":"Aggressive Presentation of Streptococcus Constellatus","volume":"13","author":"Vulisha A. 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