{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:15:11Z","timestamp":1784034911333,"version":"3.55.0"},"reference-count":56,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22575119"],"award-info":[{"award-number":["22575119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005145","name":"Basic Research Program of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20251860"],"award-info":[{"award-number":["BK20251860"]}],"id":[{"id":"10.13039\/501100005145","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2026,7,14]]},"abstract":"<jats:p>\n                    Allergic dermatitis (AD) requires long\u2010term management, yet conventional systemic therapies are frequently limited by adverse effects and inadequate lesion\u2010specific delivery. Herein, we report a mechanically reinforced composite dissolvable microneedle (MN) patch (L\u2010Cys@HAMN) for localized endogenous thiol delivery in AD treatment. The patch consists of L\u2010cysteine\u2010loaded hyaluronic acid (HA) microneedle tips integrated with an elastic poly(n\u2010butyl acrylate) (PBA) backing layer, enabling efficient force transmission and consistent skin penetration while minimizing structural deformation. Upon insertion, the dissolvable MN tips rapidly release L\u2010cysteine into the viable epidermis, where it is enzymatically converted into hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) to suppress inflammatory responses. In vitro studies demonstrated significant downregulation of proinflammatory cytokines, including TNF\u2010\u03b1 and IL\u20106. In a passive cutaneous anaphylaxis mouse model, L\u2010Cys@HAMN markedly alleviated inflammatory infiltration and reduced local inflammatory burden compared with control treatments. In addition, the HA\u2010based matrix provided auxiliary moisturizing and barrier\u2010supporting effects. Collectively, this work presents a mechanically robust and therapeutically effective MN platform for localized endogenous thiol delivery and offers a promising strategy for AD management.\n                  <\/jats:p>","DOI":"10.1002\/cbic.70455","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:54:01Z","timestamp":1783331641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Composite Dissolvable Microneedle\u2010Enabled Local High\u2010Dose Delivery of Endogenous Thiols for Efficient Allergic Dermatitis Treatment"],"prefix":"10.1002","volume":"27","author":[{"given":"Lanlan","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) School of Flexible Electronics (Future Technologies)  Nanjing Tech University (Nanjing Tech)  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) School of Flexible Electronics (Future Technologies)  Nanjing Tech University (Nanjing Tech)  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizi","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) School of Flexible Electronics (Future Technologies)  Nanjing Tech University (Nanjing Tech)  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyi","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) School of Flexible Electronics (Future Technologies)  Nanjing Tech University (Nanjing Tech)  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) School of Flexible Electronics (Future Technologies)  Nanjing Tech University (Nanjing Tech)  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) School of Flexible Electronics (Future Technologies)  Nanjing Tech University (Nanjing Tech)  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyun","family":"Lv","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) School of Flexible Electronics (Future Technologies)  Nanjing Tech University (Nanjing Tech)  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) School of Flexible Electronics (Future Technologies)  Nanjing Tech University (Nanjing Tech)  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8841-2373","authenticated-orcid":false,"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) School of Flexible Electronics (Future Technologies)  Nanjing Tech University (Nanjing Tech)  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1996.tb00646.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204184"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04344"},{"key":"e_1_2_11_5_1","first-page":"11","volume":"11","author":"Zhang J.","year":"2025","journal-title":"Allergens in Atopic Dermatitis. 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