{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:35:56Z","timestamp":1786725356712,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:p>\n                    The rapid progress of multidrug\u2010resistant (MDR) bacterial infections and the clinical aggressiveness of triple\u2010negative breast cancer (TNBC) possess a great problem to human beings. It necessitates the discovery and development of multifunctional therapeutic biomaterials. Herein, we report two enzymatically stable short cationic peptide hydrogelators comprising of N\u2010terminal lysine headgroups, non\u2010coded amino acid spacers, aromatic phenylalanine residues, and dodecylamine tails. These amphiphilic peptides are rapidly self\u2010assembled in Tris\u2010HCl buffer (pH 7.4) to form hydrogels with nanofibrillar network. Remarkably, both of these hydrogelators exhibit potent antibacterial activity against several Gram\u2010positive and Gram\u2010negative drug\u2010resistant strains, functioning through multitiered mechanism including membrane permeabilization, trans\u2010membrane depolarization, and intracellular reactive oxygen species (ROS) generation. Moreover, one of these peptide amphiphiles demonstrates a significant anticancer efficacy (with IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 6.9\u2009\u00b5M) against human TNBC cells by activating the extrinsic caspase\u20108\/caspase\u20103\u2010driven apoptotic pathway and reversing epithelial\u2010to\u2010mesenchymal transition (EMT). Interestingly, the peptide with centrally located amino acid residue with lesser number of methylene units than that of the other peptide shows better anticancer efficacy and less antimicrobial activity. This study vividly demonstrates a tunable class of proteolytically stable amphiphilic peptide gelators with potential antimicrobial as well as anticancer activities establishing a structure\u2010function relationship of these bioactive peptide scaffolds suggesting a versatile blueprint for peptide\u2010based next\u2010generation soft bioactive materials.\n                  <\/jats:p>","DOI":"10.1002\/cbic.70478","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:12:10Z","timestamp":1786720330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structure\u2010Function Regulation of Proteolytically Stable Amphiphilic Peptide\u2010Based Soft Materials With Antimicrobial Efficacy Against Drug\u2010Resistant Strains and Anticancer Activity in Triple\u2010Negative Breast Cancer Cells"],"prefix":"10.1002","volume":"27","author":[{"given":"Supratim","family":"Bose","sequence":"first","affiliation":[{"name":"School of Biological Sciences Indian Association for the Cultivation of Science  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananya","family":"Das","sequence":"additional","affiliation":[{"name":"Chittaranjan National Cancer Institute  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8815-8219","authenticated-orcid":false,"given":"Swapnendu","family":"Deb","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Indian Association for the Cultivation of Science  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanushree","family":"Mondal","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Indian Association for the Cultivation of Science  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4025-9426","authenticated-orcid":false,"given":"Nabanita","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Chittaranjan National Cancer Institute  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1309-921X","authenticated-orcid":false,"given":"Arindam","family":"Banerjee","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Indian Association for the Cultivation of Science  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"100947","DOI":"10.1016\/j.lanmic.2024.07.010","article-title":"Antimicrobial Resistance: A Concise Update","volume":"6","author":"Ho C. 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