{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:44:28Z","timestamp":1791967468417,"version":"4.3.4"},"reference-count":86,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2026,9,14]]},"abstract":"<jats:p>Biocatalysis is becoming a strategic manufacturing capability at AstraZeneca, enabling selective transformations under milder conditions and with the potential to reduce waste and resource intensity relative to conventional routes. This review summarizes how AstraZeneca is embedding biocatalysis across the portfolio to support its long\u2010term net\u2010zero commitments. We describe capability building across people, through expansion of cross\u2010site expertise, automated high\u2010throughput experimentation platforms, and academic partnerships that extend innovation and capacity. Case studies show how enzyme identification, optimization, and directed evolution translate into robust, scalable processes for active pharmaceutical ingredients. We close by defining priorities\u2014end\u2010to\u2010end automated workflows and artificial intelligence\u2010enabled design\u2014to shorten enzyme engineering cycles and broaden biocatalysis impact across modalities.<\/jats:p>","DOI":"10.1002\/cbic.70489","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:08:13Z","timestamp":1789373293000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Next\u2010Generation Manufacturing: The Evolving Role of Biocatalysis in AstraZeneca"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5707-7998","authenticated-orcid":false,"given":"Alba","family":"Diaz\u2010Rodriguez","sequence":"first","affiliation":[{"name":"Early Chemical Development Pharmaceutical Sciences Biopharmaceuticals R&amp;D AstraZeneca  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-8464","authenticated-orcid":false,"given":"Martin A.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Discovery Sciences Biopharmaceuticals R&amp;D AstraZeneca  Gothenburg Sweden"},{"name":"School of Chemistry and Molecular Biosciences The University of Queensland  St Lucia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith R.","family":"Mulholland","sequence":"additional","affiliation":[{"name":"Chemical Development Process Technology and Development Operations AstraZeneca  Macclesfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8570-2479","authenticated-orcid":false,"given":"Fernando","family":"Tur","sequence":"additional","affiliation":[{"name":"Early Chemical Development Pharmaceutical Sciences Biopharmaceuticals R&amp;D AstraZeneca  Macclesfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Staniland","sequence":"additional","affiliation":[{"name":"Oncology R&amp;D AstraZeneca  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclepro.2018.11.204"},{"key":"e_1_2_8_3_1","unstructured":"AstraZeneca Sustainability: Climate Change https:\/\/www.astrazeneca.com\/sustainability\/climate\u2010change.html accessed July 2025."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat0805"},{"key":"e_1_2_8_5_1","volume-title":"Green Chemistry: Theory and Practice","author":"Anastas P. T.","year":"1998"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/B918763B"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6GC02901A"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17518250903258150"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay3060"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202000317"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.7b03505"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8GC01276H"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-021-00044-z"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.1c00467"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.2c00712"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c00812"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202505976"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.7b00114"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.4c00224"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5c01646"},{"key":"e_1_2_8_21_1","first-page":"1052","article-title":"Green Chemistry in the Synthesis of Pharmaceuticals","volume":"122","author":"Simi\u0107 S.","year":"2022","journal-title":"Chemical Reviews"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.0c01496"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-018-0055-1"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202402316"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c06322"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0186-3"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.4c00653"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04456-z"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00972F"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c03417"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.3c01275"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.9b04321"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.3c02743"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00910"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c07969"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4NP00031E"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-019-0385-5"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adh8615"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.5c00786"},{"key":"e_1_2_8_40_1","unstructured":"Centre of Excellence for Biocatalysis Biotransformations and Biocatalytic Manufacture (CoEBio3) https:\/\/www.manchester.ac.uk\/research\/impact\/showcase\/driving\u2010the\u2010industrial\u2010biotechnology\u2010revolution\/ accessed March 2026."},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-018-0159-5"},{"key":"e_1_2_8_42_1","unstructured":"AZ PostDoc Programme https:\/\/careers.astrazeneca.com\/r\u2010d\u2010postdoc\u2010astrazeneca accessed March 2026."},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00030"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202207831"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c00482"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202313912"},{"key":"e_1_2_8_47_1","unstructured":"Manchester Institute of Biotechnology https:\/\/www.mib.manchester.ac.uk\/research\/centres\/coebio3\/ accessed March 2026."},{"key":"e_1_2_8_48_1","unstructured":"Industrial Doctoral Landscape Awards (IDLAs) \u2010 UK Research and Innovation https:\/\/www.ukri.org\/news\/ukri\u2010doctoral\u2010training\u2010investment\u2010set\u2010to\u2010power\u2010uk\u2010growth\/ accessed March 2026."},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.202102592"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44160-024-00563-z"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202513289"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44160-024-00671-w"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-022-00889-x"},{"key":"e_1_2_8_54_1","unstructured":"Mistra SafeChem research programme https:\/\/mistrasafechem.se\/ accessed March 2026."},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201804592"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4GC03665D"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.70232"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202014931"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c07010"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c05231"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-025-01161-9"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202300382"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5SC05480J"},{"key":"e_1_2_8_64_1","unstructured":"PharmEco Consortium https:\/\/pharmeco.eu\/ accessed March 2026."},{"key":"e_1_2_8_65_1","unstructured":"BiodeCCodiNNg Consortium https:\/\/biodeccodinng.eu\/ accessed March 2026."},{"key":"e_1_2_8_66_1","unstructured":"Haloverse Consortium https:\/\/haloverse.eu\/ accessed March 2026."},{"key":"e_1_2_8_67_1","unstructured":"CirculH2 Consortium https:\/\/www.circulh2.com\/ accessed March 2026."},{"key":"e_1_2_8_68_1","unstructured":"Elegance Consortium https:\/\/cordis.europa.eu\/project\/id\/101226960 accessed Mar 2026."},{"key":"e_1_2_8_69_1","unstructured":"NextMarine Consortium https:\/\/euromarinenetwork.eu\/news\/nextmarine\u2010pioneering\u2010discovery\u2010in\u2010extreme\u2010marine\u2010environments\/ accessed March 2026."},{"key":"e_1_2_8_70_1","unstructured":"C\u2010Loop Initiative https:\/\/www.nottingham.ac.uk\/news\/c\u2010loop\u2010ukri accessed March 2026."},{"key":"e_1_2_8_71_1","unstructured":"AstraZeneca's BioVentureHub https:\/\/www.azbioventurehub.com\/ accessed March 2026."},{"key":"e_1_2_8_72_1","unstructured":"AstraZeneca's BioVentureHub SustainTech https:\/\/www.azbioventurehub.com\/Shaping\u2010a\u2010Sustainable\u2010Future\u2010With\u2010SustainTech.html accessed March 2026."},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(20000417)39:8<1352::AID-ANIE1352>3.0.CO;2-J"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.200600020"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0307563101"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.0c00120"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.7b00230"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188934"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/op400131h"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/op400133d"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja972012z"},{"key":"e_1_2_8_82_1","unstructured":"A. R.Turner A. T.Turner G. P.Howell et al. \u201cImproved Method for the Manufacture of 3\u2010[(1S)\u20101\u2010Imidazo[1 2\u2010a]pyridin\u20106\u2010Ylethyl]\u20105\u2010(1\u2010Methylpyrazol\u20104\u2010Yl)triazolo[4 5\u2010b]pyrazine and Polymorphic Forms Thereof \u201d WO 2020053198 A1 (2020)."},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00338a030"},{"key":"e_1_2_8_84_1","unstructured":"G.Huisman Communication to the 13th Dutch Congress in Biotechnology Amsterdam The Netherlands(2010)."},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.6b00391"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.9b00075"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.0c00482"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.70489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbic.70489","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.70489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:45:46Z","timestamp":1791963946000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.70489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,14]]},"references-count":86,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9,14]]}},"alternative-id":["10.1002\/cbic.70489"],"URL":"https:\/\/doi.org\/10.1002\/cbic.70489","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,14]]},"assertion":[{"value":"2026-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70489"}}