{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:36:05Z","timestamp":1786725365198,"version":"build-2736575974"},"reference-count":71,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006021","name":"Direction G\u00e9n\u00e9rale de l\u2019Armement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:p>\n                    About 50 years after their development, the benzimidazole anthelmintic drugs still occupy a key role in the treatment of parasitic diseases. Like other anti\u2010infective drugs, their extensive use has led to resistance development and now requires new solutions to treat these diseases. Organometallic derivatization of existing drugs has become a common strategy to design new drug candidates, which could benefit from enhanced activity against resistant or sensitive strains through the incorporation of an organometallic fragment. In this study, we describe the development of a new series of organometallic derivatives of benzimidazole anthelmintics. Ten derivatives, six of which were organometallic, were synthesized and characterized. In silico and in vitro studies were performed to determine their biological activity. Therefore, they were screened against a range of nematodes and other parasites. Biological activities were found for some of the derivatives against\n                    <jats:italic>Strongyloides ratti<\/jats:italic>\n                    ,\n                    <jats:italic>Ancylostoma ceylanicum<\/jats:italic>\n                    ,\n                    <jats:italic>Trichuris muris<\/jats:italic>\n                    ,\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    ,\n                    <jats:italic>Echinococcus multilocularis,<\/jats:italic>\n                    or\n                    <jats:italic>Leishmania infantum<\/jats:italic>\n                    in similar ranges as the parent anthelmintics. Even if the activity of the benzimidazole scaffold was not systematically enhanced, this strategy is a good starting point for the development of new antiparasitic compounds and for further study of the mode of action of these drugs.\n                  <\/jats:p>","DOI":"10.1002\/cbic.70490","type":"journal-article","created":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T11:15:46Z","timestamp":1786274146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and Antiparasitic Activities of New Organometallic Derivatives of the Benzimidazole Anthelmintic Drugs"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3466-9943","authenticated-orcid":false,"given":"Corentin","family":"Ludwig","sequence":"first","affiliation":[{"name":"Chimie ParisTech PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3489-4367","authenticated-orcid":false,"given":"Aya C.","family":"Taki","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences Melbourne Veterinary School Faculty of Science The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5235-8408","authenticated-orcid":false,"given":"Joseph J.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences Melbourne Veterinary School Faculty of Science The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1069-2138","authenticated-orcid":false,"given":"Pierre","family":"Mesdom","sequence":"additional","affiliation":[{"name":"Chimie ParisTech PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9857-4042","authenticated-orcid":false,"given":"Olivier","family":"Blacque","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1282-8070","authenticated-orcid":false,"given":"C\u00e9cile","family":"H\u00e4berli","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute  Allschwil Switzerland"},{"name":"University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3614-4930","authenticated-orcid":false,"given":"Trix","family":"Zumkehr","sequence":"additional","affiliation":[{"name":"Institute of Parasitology Vetsuisse Faculty University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5386-6225","authenticated-orcid":false,"given":"Gonzalo","family":"Scalese","sequence":"additional","affiliation":[{"name":"\u00c1rea Qu\u00edmica Inorg\u00e1nica Facultad de Qu\u00edmica Universidad de la Rep\u00fablica  Montevideo Uruguay"},{"name":"Laboratory Redox Biology of Trypanosomes Institut Pasteur de Montevideo  Montevideo Uruguay"},{"name":"Secci\u00f3n Gen\u00f3mica Funcional Facultad de Ciencias Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5084-7619","authenticated-orcid":false,"given":"Leticia","family":"P\u00e9rez\u2010D\u00edaz","sequence":"additional","affiliation":[{"name":"Secci\u00f3n Gen\u00f3mica Funcional Facultad de Ciencias Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8678-7374","authenticated-orcid":false,"given":"Dinorah","family":"Gambino","sequence":"additional","affiliation":[{"name":"\u00c1rea Qu\u00edmica Inorg\u00e1nica Facultad de Qu\u00edmica Universidad de la Rep\u00fablica  Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2672-5766","authenticated-orcid":false,"given":"Britta","family":"Lundstr\u00f6m\u2010Stadelmann","sequence":"additional","affiliation":[{"name":"Institute of Parasitology Vetsuisse Faculty University of Bern  Bern Switzerland"},{"name":"Multidisciplinary Center for Infectious Diseases University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0290-3521","authenticated-orcid":false,"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute  Allschwil Switzerland"},{"name":"University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4423-1690","authenticated-orcid":false,"given":"Robin B.","family":"Gasser","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences Melbourne Veterinary School Faculty of Science The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5854-9632","authenticated-orcid":false,"given":"Kevin","family":"Cariou","sequence":"additional","affiliation":[{"name":"Chimie ParisTech PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4244-5097","authenticated-orcid":false,"given":"Gilles","family":"Gasser","sequence":"additional","affiliation":[{"name":"Chimie ParisTech PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(09)61422\u20107"},{"key":"e_1_2_9_3_1","unstructured":"Accelerating Work to Overcome the Global Impact of Neglected Tropical Diseases (World Health Organization 2012)."},{"key":"e_1_2_9_4_1","unstructured":"Ending the Neglect to Attain the Sustainable Development Goals: A Road Map for Neglected Tropical Diseases 2021\u20102030 (World Health Organization 2021)."},{"key":"e_1_2_9_5_1","unstructured":"Global Report on Neglected Tropical Diseases 2024 (World Health Organization 2024)."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.16.1911"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4414\/smw.2012.13727"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102885.1990.tb00773.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.136716"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0DT01107J"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01924165"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00245a029"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01919842"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0001\u2010706X(94)90066\u20103"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090\u20100233(05)80005\u2010X"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014\u20104894(91)90023\u2010P"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169\u20104758(90)90227\u2010U"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2004.08.001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2013.01.007"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fitd.2022.898814"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201016765\u20104"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2016.06.021"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201904699"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010017\u20100066"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm970401y"},{"key":"e_1_2_9_26_1","unstructured":"Investigation of the Redox Behavior of Ferroquine a New Antimalarial | Molecular Pharmaceutics https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/mp800007x."},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb100322v"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2011183207"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2019.06.004"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CS01216J"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2016.07.001"},{"key":"e_1_2_9_32_1","first-page":"181","volume-title":"Advances in Parasitology","author":"Besier R. B.","year":"2016"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281\u2010012\u20100348\u20102"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182016000020"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281\u2010012\u20100347\u20103"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014\u20104894(78)90078\u20104"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2021.04.013"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2019.05.005"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2025.01.034"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2020.06.003"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.11120.1"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.5b02936"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/B308412D"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8DT03440K"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2011.01.047"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr100264t"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2013.04.002"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1CE05624G"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010biochem\u2010030222\u2010120000"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096\u2010987X(19981115)19:14<1639:AID\u2010JCC10>3.0.CO;2\u2010B"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26144156"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14070616"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1014804"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/jctb.503310110"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071\u2010022\u201005253\u20103"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00719"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004360050411"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169\u20104758(90)90228\u2010V"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2009.11.001"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.5.1052"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.2307\/3279218"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011343"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp490"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.38.9.2086"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001\u2010706X(99)00034\u20100"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2022.112016"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5DT00241A"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.5c02730"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003118201300142X"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm070845m"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2014070"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.70490","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbic.70490","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.70490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:02:51Z","timestamp":1786723371000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.70490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,9]]},"references-count":71,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2026,8,14]]}},"alternative-id":["10.1002\/cbic.70490"],"URL":"https:\/\/doi.org\/10.1002\/cbic.70490","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,9]]},"assertion":[{"value":"2026-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70490"}}