{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:44:28Z","timestamp":1791967468297,"version":"4.3.4"},"reference-count":424,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2026,9,14]]},"abstract":"<jats:p>Biocascade catalysis has emerged as a defining paradigm in contemporary synthesis, enabling the orchestration of multiple enzymatic transformations within a single vessel. By allowing intermediates to flow seamlessly between successive steps without isolation, cascades emulate the elegance of natural biosynthetic networks while delivering significant gains in atom economy and operational simplicity. The intrinsic chemo\u2010, regio\u2010, and stereoselectivity of enzymes facilitates the construction of architecturally complex, enantiomerically enriched molecules under mild, aqueous, and environmentally benign conditions. In this way, biocascade strategies accelerate the generation of molecular diversity while embodying the principles of sustainable chemistry by reducing energy demand, solvent use, and waste generation. Recent advances in protein engineering, directed evolution, computational enzyme design, and synthetic biology have expanded the scope of enzymatic cascades, transforming nature's catalytic repertoire into scalable synthetic technologies. Landmark studies now demonstrate their transformative potential in the assembly of complex polyketides, bioactive alkaloids, pharmaceuticals, and active pharmaceutical ingredients (APIs), as well as diverse heterocyclic scaffolds of medicinal relevance. Collectively, these achievements underscore the growing significance of biocascade catalysis as a cornerstone of modern synthesis, bridging the ingenuity of biological systems with the imperatives of next\u2010generation drug discovery and sustainable chemical manufacturing.<\/jats:p>","DOI":"10.1002\/cbic.70492","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:46:16Z","timestamp":1788201976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sustainable Biocatalytic Cascades: A Versatile Tool in the Synthesis of Natural Products With Therapeutic Potential"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6094-3447","authenticated-orcid":false,"given":"Ram N.","family":"Yadav","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Engineering and Technology Veer Bahadur Singh Purvanchal University  Jaunpur Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9770-5723","authenticated-orcid":false,"given":"Sovan","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of North Bengal  Darjeeling West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7839-567X","authenticated-orcid":false,"given":"Satyendra Kumar","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Chemistry Institute of Science Banaras Hindu University  Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anup","family":"Barman","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of North Bengal  Darjeeling West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1199-7881","authenticated-orcid":false,"given":"Md. Firoj","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of North Bengal  Darjeeling West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7059-3938","authenticated-orcid":false,"given":"Luciana C.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Instituto de Tecnolog\u00eda Qu\u00edmica Universitat Polit\u00e8cnica de Val\u00e8ncia\u2010Consejo Superior de Investigaciones Cient\u00edficas  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1898-8497","authenticated-orcid":false,"given":"Vandana","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Allahabad  Prayagraj Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"The Background to Eduard Buchner's Discovery of Cell\u2010Free Fermentation on JSTOR https:\/\/www.jstor.org\/stable\/4330549(accessed 25 December 2025). n.d."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.9b02737"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6729453"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.10.3192"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physchem-090519-050109"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2020.12.013"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/op0340311"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201807844"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2459"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41002-5"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00689A"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC08752F"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00073"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2024.102919"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-022-00931-2"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201100256"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.7b03440"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b04921"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2020.08.006"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-020-0433-1"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.1c01742"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr0301189"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1071\/CH09104"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/07357909909011730"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.9.12.2783"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/fermentation10120645"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-016-1847-2"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802608784221479"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201001279"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5RA03414K"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520623666230207122157"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/md16010025"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2004190117"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-27955-z"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo301592k"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.3c00282"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.156.3772.202"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4NP00098F"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.02.001"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c03750"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5b00477"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2017.111"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2020.12.007"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ces.2004.09.026"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.3c00183"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/cs9871600123"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/md16070236"},{"key":"e_1_2_12_49_1","doi-asserted-by":"crossref","unstructured":"P.Comba \u201cModeling of Molecular Properties \u201d2011 https:\/\/doi.org\/10.1002\/9783527636402.","DOI":"10.1002\/9783527636402"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja051586y"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.5c00539"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NP00025A"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1893"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.4c00567"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NP00109A"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3NP00060E"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.35534\/sbe.2024.10012"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.1017190"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2010.130"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-5521(02)00095-9"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr960027u"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(09)04606-0"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28020798"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics8040157"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr12071533"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R110.144618"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00638597"},{"key":"e_1_2_12_68_1","first-page":"284","article-title":"Pikromycin, A Bitter\u2010Tasting Antibiotic From Actinomycetes (Antibiotics From Actinomycetes, VI)","volume":"84","author":"Brockmann H.","year":"1951","journal-title":"Chemical Reports"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr9600316"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1039\/b009329g"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/27.suppl_A.1"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.200805334"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24299"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics5030029"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161060-00016"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2009.06.013"},{"key":"e_1_2_12_77_1","first-page":"761","article-title":"Review of Macrolides (Azithromycin, Clarithromycin), Ketolids (Telithromycin) and Glycylcyclines (Tigecycline)","volume":"95","author":"Zuckerman J. M.","year":"2011","journal-title":"Medical Clinics"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2004.04.010"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja404134f"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02296-07"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-006-0318-5"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.29.1171"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/md11041152"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b02875"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2010.5"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00064a011"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja974009l"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja974010k"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401247101"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo101124n"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201107386"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201407806"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09981"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0649670"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja076580i"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi5003629"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-020-01367-4"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar8002249"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202200775"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2465"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr960019d"},{"key":"e_1_2_12_102_1","doi-asserted-by":"crossref","unstructured":"M.Mets\u00e4\u2010Ketel\u00e4 J.Niemi P.M\u00e4nts\u00e4l\u00e4 andG.Schneider \u201cAnthracycline Biosynthesis: Genes Enzymes and Mechanisms \u201d2007 101\u2013140.","DOI":"10.1007\/128_2007_14"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NP00059D"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.72.4.2573-2580.2006"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-013-5373-0"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.28019-0"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1006\/bioo.1998.1110"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1NP00068C"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(02)00889-2"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41429-018-0139-7"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.1c00208"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-018-2448-1"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2012.08.006"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00063"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-014-5952-8"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-018-02131-9"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-12-169"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-85498-4_6"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi200593m"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NP00048B"},{"key":"e_1_2_12_121_1","first-page":"E6844","article-title":"Structural and Functional Analysis of Two Di\u2010Domain Aromatase\/Cyclases From Type II Polyketide Synthases","volume":"112","author":"Caldara\u2010Festin G.","year":"2015","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1039\/b911956f"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00103a001"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja960479o"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NP00112A"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201911255"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr960022x"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1039\/B507395M"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00216-6"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.65.2.232-260.2001"},{"key":"e_1_2_12_131_1","unstructured":"B.Duggar \u201cAureomycin\u2010A New Antibiotic \u201d1948 https:\/\/doi.org\/10.5555\/19492703096."},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.4137\/CMT.S2035"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10070757"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JBC.2021.100328"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.0c00482"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26167801"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5NP00049A"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64995-1"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M703437200"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R110.130419"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases4010003"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(98)01935-2"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880200903433760"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)84643-9"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(99)00080-1"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1093\/jexbot\/52.363.2015"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c02772"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.4c04412"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201910882"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.1c01226"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2024.108672"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-020-10782-x"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)39079-2"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1111"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3260919"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl063"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115474"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi8023509"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2012.02.088"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c02438"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NP00026D"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-008-9199-7"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.8b00015"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05821-1"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-009-9218-3"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112791"},{"key":"e_1_2_12_167_1","first-page":"272010","article-title":"Tetracycline Resistance Genes Identified From Distinct Soil Environments in China by Functional Metagenomics","volume":"8","author":"Wang S.","year":"2017","journal-title":"Frontiers in Microbiology"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c03788"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025387"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb400541z"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569540802462040"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.3891\/acta.chem.scand.51-0855"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00031"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2008.84"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2014.2659"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307625200"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol303435y"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c03283"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NP00046F"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.635268"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.26.65"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c04834"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.41.741"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.41.502"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c02311"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2011.91"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(03)00189-4"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c12895"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.37.1091"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.45.1681"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b12736"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2013.06.032"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-07-0211"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm900075g"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1038\/314642a0"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.1c00227"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c08803"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2020.12.011"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja207662w"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103921108"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c18376"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c06089"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.1c01089"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11538-6"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC01712D"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c09101"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.26.16184"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8248802"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709223105"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(09)04601-1"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.9b00827"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2022.07.002"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202218660"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1218524110"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c17551"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c02185"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00979a037"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c03432"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201804991"},{"key":"e_1_2_12_220_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c11226"},{"key":"e_1_2_12_221_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118391815"},{"key":"e_1_2_12_222_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr3004778"},{"key":"e_1_2_12_223_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00032a009"},{"key":"e_1_2_12_224_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201709056"},{"key":"e_1_2_12_225_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17040232"},{"key":"e_1_2_12_226_1","doi-asserted-by":"publisher","DOI":"10.1021\/np500757w"},{"key":"e_1_2_12_227_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-013-4921-x"},{"key":"e_1_2_12_228_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c07754"},{"key":"e_1_2_12_229_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja3090498"},{"key":"e_1_2_12_230_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr300402y"},{"key":"e_1_2_12_231_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c08761"},{"key":"e_1_2_12_232_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.3c01405"},{"key":"e_1_2_12_233_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC05413J"},{"key":"e_1_2_12_234_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.6b00355"},{"key":"e_1_2_12_235_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1OB00875G"},{"key":"e_1_2_12_236_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00151"},{"key":"e_1_2_12_237_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c13197"},{"key":"e_1_2_12_238_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.80631"},{"key":"e_1_2_12_239_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.27.597"},{"key":"e_1_2_12_240_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00349a040"},{"key":"e_1_2_12_241_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10865"},{"key":"e_1_2_12_242_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja511374k"},{"key":"e_1_2_12_243_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf903259n"},{"key":"e_1_2_12_244_1","doi-asserted-by":"publisher","DOI":"10.1039\/c39740000874"},{"key":"e_1_2_12_245_1","doi-asserted-by":"publisher","DOI":"10.1021\/np070494e"},{"key":"e_1_2_12_246_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b07816"},{"key":"e_1_2_12_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2018.05.020"},{"key":"e_1_2_12_248_1","doi-asserted-by":"publisher","DOI":"10.1021\/np500143k"},{"key":"e_1_2_12_249_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c17188"},{"key":"e_1_2_12_250_1","unstructured":"\u201cThe Diels\u2013Alder Reaction in Total Synthesis \u2010 Nicolaou \u2010 2002 \u2010 Angewandte Chemie International Edition \u2010 Wiley Online Library \u201dhttps:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1521\u20103773(20020517)41:10%3C1668::AID\u2010ANIE1668%3E3.0.CO;2\u2010Z(accessed 20 February 2026).n.d."},{"key":"e_1_2_12_251_1","doi-asserted-by":"publisher","DOI":"10.1039\/B305068H"},{"key":"e_1_2_12_252_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201805050"},{"key":"e_1_2_12_253_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b10452"},{"key":"e_1_2_12_254_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201500386"},{"key":"e_1_2_12_255_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1769"},{"key":"e_1_2_12_256_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8np00075a"},{"key":"e_1_2_12_257_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.24.653"},{"key":"e_1_2_12_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)93121-6"},{"key":"e_1_2_12_259_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.03.023"},{"key":"e_1_2_12_260_1","doi-asserted-by":"publisher","DOI":"10.3390\/md15080253"},{"key":"e_1_2_12_261_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b02204"},{"key":"e_1_2_12_262_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201200624"},{"key":"e_1_2_12_263_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201904360"},{"key":"e_1_2_12_264_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC09512J"},{"key":"e_1_2_12_265_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b01083"},{"key":"e_1_2_12_266_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201705237"},{"key":"e_1_2_12_267_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NP00056J"},{"key":"e_1_2_12_268_1","doi-asserted-by":"publisher","DOI":"10.1039\/b704420h"},{"key":"e_1_2_12_269_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c04685"},{"key":"e_1_2_12_270_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12040210"},{"key":"e_1_2_12_271_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-019-09602-6"},{"key":"e_1_2_12_272_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26113374"},{"key":"e_1_2_12_273_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-019-02656-0"},{"key":"e_1_2_12_274_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780429259968-10"},{"key":"e_1_2_12_275_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8749083"},{"key":"e_1_2_12_276_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2015.12.003"},{"key":"e_1_2_12_277_1","first-page":"1","volume-title":"Alkaloids: A Treasury of Poisons and Medicines","author":"Funayama S.","year":"2014"},{"key":"e_1_2_12_278_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.arplant.52.1.29"},{"key":"e_1_2_12_279_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22020250"},{"key":"e_1_2_12_280_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16119665"},{"key":"e_1_2_12_281_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557521666210712111331"},{"key":"e_1_2_12_282_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/485042"},{"key":"e_1_2_12_283_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202000120"},{"key":"e_1_2_12_284_1","doi-asserted-by":"publisher","DOI":"10.2174\/1385272821666170207114214"},{"key":"e_1_2_12_285_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins16110489"},{"key":"e_1_2_12_286_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.06.001"},{"key":"e_1_2_12_287_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10030318"},{"key":"e_1_2_12_288_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867322666150716114912"},{"key":"e_1_2_12_289_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2026.111716"},{"key":"e_1_2_12_290_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prenap.2023.100006"},{"key":"e_1_2_12_291_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar500427k"},{"key":"e_1_2_12_292_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-015-9451-z"},{"key":"e_1_2_12_293_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-023-09901-z"},{"key":"e_1_2_12_294_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50010a002"},{"key":"e_1_2_12_295_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA04181A"},{"key":"e_1_2_12_296_1","doi-asserted-by":"publisher","DOI":"10.3390\/md20060368"},{"key":"e_1_2_12_297_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm700948z"},{"key":"e_1_2_12_298_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2019.12.008"},{"key":"e_1_2_12_299_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12870-024-05412-x"},{"key":"e_1_2_12_300_1","doi-asserted-by":"publisher","DOI":"10.1080\/07388551.2024.2383754"},{"key":"e_1_2_12_301_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.200900229"},{"key":"e_1_2_12_302_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2007.7"},{"key":"e_1_2_12_303_1","doi-asserted-by":"publisher","DOI":"10.1111\/pbi.12494"},{"key":"e_1_2_12_304_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2006.02.005"},{"key":"e_1_2_12_305_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol027232i"},{"key":"e_1_2_12_306_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00316a077"},{"key":"e_1_2_12_307_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201300718"},{"key":"e_1_2_12_308_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.10728"},{"key":"e_1_2_12_309_1","doi-asserted-by":"publisher","DOI":"10.34133\/BDR.0048"},{"key":"e_1_2_12_310_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-008-9240-4"},{"key":"e_1_2_12_311_1","doi-asserted-by":"publisher","DOI":"10.1006\/pmpp.2001.0371"},{"key":"e_1_2_12_312_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b03317"},{"key":"e_1_2_12_313_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15270"},{"key":"e_1_2_12_314_1","doi-asserted-by":"publisher","DOI":"10.1021\/np200954v"},{"key":"e_1_2_12_315_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja028538n"},{"key":"e_1_2_12_316_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5c00753"},{"key":"e_1_2_12_317_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c06631"},{"key":"e_1_2_12_318_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21081078"},{"key":"e_1_2_12_319_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23102585"},{"key":"e_1_2_12_320_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200890074"},{"key":"e_1_2_12_321_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2017.1386658"},{"key":"e_1_2_12_322_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38129"},{"key":"e_1_2_12_323_1","doi-asserted-by":"crossref","unstructured":"C. K.Yu D. B.MacLean R. G. A.Rodrigo andR. H. F.Manske \u201cStructural and Conformational Studies on Tetrahydroprotoberberine Alkaloids48(1970):3673\u20133678 https:\/\/doi.org\/10.1139\/v70\u2010616.","DOI":"10.1139\/v70-616"},{"key":"e_1_2_12_324_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01116a016"},{"key":"e_1_2_12_325_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c02110"},{"key":"e_1_2_12_326_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57280-0"},{"key":"e_1_2_12_327_1","first-page":"30","article-title":"Use of Vasodilators to Overcome Perioperative Spasm of the Left Internal Mammary Artery and Saphenous Vein in Coronary Artery Bypass Grafting: Comparison of","volume":"11","author":"Shafa M.","year":"2017","journal-title":"International Cardiovascular Research Journal"},{"key":"e_1_2_12_328_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00709-014-0633-0"},{"key":"e_1_2_12_329_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5688(06)81865-9"},{"key":"e_1_2_12_330_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.296"},{"key":"e_1_2_12_331_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201902761"},{"key":"e_1_2_12_332_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44420-7"},{"key":"e_1_2_12_333_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202513926"},{"key":"e_1_2_12_334_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.5c03626"},{"key":"e_1_2_12_335_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5c01322"},{"key":"e_1_2_12_336_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay8484"},{"key":"e_1_2_12_337_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c01431"},{"key":"e_1_2_12_338_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.4c00075"},{"key":"e_1_2_12_339_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c00239"},{"key":"e_1_2_12_340_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.0c00304"},{"key":"e_1_2_12_341_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.4c00368"},{"key":"e_1_2_12_342_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.0c00476"},{"key":"e_1_2_12_343_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz7376"},{"key":"e_1_2_12_344_1","doi-asserted-by":"publisher","DOI":"10.1126\/SCITRANSLMED.ABB5883"},{"key":"e_1_2_12_345_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03312-w"},{"key":"e_1_2_12_346_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.1c00608"},{"key":"e_1_2_12_347_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00763C"},{"key":"e_1_2_12_348_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.25.271"},{"key":"e_1_2_12_349_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.56.364"},{"key":"e_1_2_12_350_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.050088-0"},{"key":"e_1_2_12_351_1","doi-asserted-by":"publisher","DOI":"10.3390\/md12020999"},{"key":"e_1_2_12_352_1","doi-asserted-by":"publisher","DOI":"10.3390\/md13010128"},{"key":"e_1_2_12_353_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18977"},{"key":"e_1_2_12_354_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2011.03.001"},{"key":"e_1_2_12_355_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1520289113"},{"key":"e_1_2_12_356_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201611063"},{"key":"e_1_2_12_357_1","doi-asserted-by":"publisher","DOI":"10.1038\/181761b0"},{"key":"e_1_2_12_358_1","doi-asserted-by":"publisher","DOI":"10.1038\/351742a0"},{"key":"e_1_2_12_359_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(95)00075-5"},{"key":"e_1_2_12_360_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201902910"},{"key":"e_1_2_12_361_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2009.12.003"},{"key":"e_1_2_12_362_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2016.04.023"},{"key":"e_1_2_12_363_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-020-10440-2"},{"key":"e_1_2_12_364_1","first-page":"E7065","article-title":"Origins of Stereoselectivity in Evolved Ketoreductases","volume":"112","author":"Noey E. L.","year":"2015","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"e_1_2_12_365_1","doi-asserted-by":"publisher","DOI":"10.1021\/cs501457v"},{"key":"e_1_2_12_366_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7OB00482F"},{"key":"e_1_2_12_367_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-019-0347-y"},{"key":"e_1_2_12_368_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1286"},{"key":"e_1_2_12_369_1","doi-asserted-by":"publisher","DOI":"10.1039\/B919115C"},{"key":"e_1_2_12_370_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160430"},{"key":"e_1_2_12_371_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.5.2164"},{"key":"e_1_2_12_372_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03009863"},{"key":"e_1_2_12_373_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00795-0"},{"key":"e_1_2_12_374_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00019a001"},{"key":"e_1_2_12_375_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00144a012"},{"key":"e_1_2_12_376_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.9b01081"},{"key":"e_1_2_12_377_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b07024"},{"key":"e_1_2_12_378_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202404537"},{"key":"e_1_2_12_379_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1736233"},{"key":"e_1_2_12_380_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.202300427"},{"key":"e_1_2_12_381_1","doi-asserted-by":"publisher","DOI":"10.1515\/psr-2021-0021"},{"key":"e_1_2_12_382_1","volume-title":"Advances in Green Synthesis. Advances in Science, Technology & Innovation","author":"Rathore D.","year":"2021"},{"key":"e_1_2_12_383_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201903455"},{"key":"e_1_2_12_384_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5md01011j"},{"key":"e_1_2_12_385_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26123719"},{"key":"e_1_2_12_386_1","first-page":"2948","article-title":"Biocatalytic and Chemo\u2010Enzymatic Approaches for the Synthesis of Heterocycles","volume":"52","author":"Zhao F.","year":"2020","journal-title":"Synthesis (Stuttg)"},{"key":"e_1_2_12_387_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.0c03755"},{"key":"e_1_2_12_388_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201810555"},{"key":"e_1_2_12_389_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201700253"},{"key":"e_1_2_12_390_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2003.09.086"},{"key":"e_1_2_12_391_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.06.048"},{"key":"e_1_2_12_392_1","doi-asserted-by":"publisher","DOI":"10.2174\/13895575113139990005"},{"key":"e_1_2_12_393_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm7014217"},{"key":"e_1_2_12_394_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.12.074"},{"key":"e_1_2_12_395_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c01186"},{"key":"e_1_2_12_396_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.3c00243"},{"key":"e_1_2_12_397_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c01175"},{"key":"e_1_2_12_398_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)89233-5"},{"key":"e_1_2_12_399_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)91624-0"},{"key":"e_1_2_12_400_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201600417"},{"key":"e_1_2_12_401_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201300539"},{"key":"e_1_2_12_402_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03841-5"},{"key":"e_1_2_12_403_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201301008"},{"key":"e_1_2_12_404_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14883"},{"key":"e_1_2_12_405_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3ra42123f"},{"key":"e_1_2_12_406_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b10053"},{"key":"e_1_2_12_407_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.759220"},{"key":"e_1_2_12_408_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c09352"},{"key":"e_1_2_12_409_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.2c01169"},{"key":"e_1_2_12_410_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c00825"},{"key":"e_1_2_12_411_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.201801166"},{"key":"e_1_2_12_412_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c03832"},{"key":"e_1_2_12_413_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c16732"},{"key":"e_1_2_12_414_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-025-01937-2"},{"key":"e_1_2_12_415_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c05902"},{"key":"e_1_2_12_416_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202411561"},{"key":"e_1_2_12_417_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.3c02314"},{"key":"e_1_2_12_418_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c18761"},{"key":"e_1_2_12_419_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201600543"},{"key":"e_1_2_12_420_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.19.1227"},{"key":"e_1_2_12_421_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b01235"},{"key":"e_1_2_12_422_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c02337"},{"key":"e_1_2_12_423_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c04498"},{"key":"e_1_2_12_424_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c08354"},{"key":"e_1_2_12_425_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c03692"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.70492","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbic.70492","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.70492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:45:58Z","timestamp":1791963958000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.70492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":424,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9,14]]}},"alternative-id":["10.1002\/cbic.70492"],"URL":"https:\/\/doi.org\/10.1002\/cbic.70492","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"2026-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70492"}}