{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:35:55Z","timestamp":1786725355733,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM146987"],"award-info":[{"award-number":["R35GM146987"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2026,8,14]]},"abstract":"<jats:p>\n                    <jats:italic>Actinoplanes teichomyceticus<\/jats:italic>\n                    is a well\u2010established producer of bioactive secondary metabolites, including the glycopeptide antibiotic teicoplanin. Although its antibiotic biosynthetic capacity has been extensively investigated, its siderophore diversity and any additional biological functions of these iron\u2010chelating metabolites remain comparatively underexplored. We identified a reproducibly bioactive, teicoplanin\u2010independent fraction that inhibited\n                    <jats:italic>Bacillus spizizenii<\/jats:italic>\n                    . Molecular networking applied to this fraction identified hydroxamate ferrioxamine and desferrioxamine\u2010type siderophores as the dominant metabolites, including acylated analogs detected as Al\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010 and Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010chelated species. Robust siderophore secretion was confirmed by the CAS assay. Notably, siderophore\u2010enriched fractions exhibited selective antibacterial activity against Gram\u2010positive bacteria, with minimum inhibitory concentrations of approximately 16 \u00b5g\/mL against\n                    <jats:italic>B. spizizenii<\/jats:italic>\n                    and partial inhibition of\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , while no activity was observed against\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    . Synthetic C7 and C9 acyl\u2010desferrioxamine analogs showed enhanced antibacterial activity upon Al\n                    <jats:sup>3+<\/jats:sup>\n                    chelation, indicating a metal\u2010dependent bioactivity. These findings reveal an unexpected antibacterial role for ferrioxamine\u2010type siderophores produced by\n                    <jats:italic>A. teichomyceticus<\/jats:italic>\n                    , extending their function beyond iron acquisition, possibly through a \u201cTrojan horse\u201d (or \u201cTrojan metal\u201d) mechanism.\n                  <\/jats:p>","DOI":"10.1002\/cbic.70496","type":"journal-article","created":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T11:18:28Z","timestamp":1786274308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Siderophores With Unexpected Antibacterial Properties From\n                    <i>Actinoplanes teichomyceticus<\/i>"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9528-5288","authenticated-orcid":false,"given":"Abiodun S.","family":"Oyedele","sequence":"first","affiliation":[{"name":"Department of 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Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangho","family":"Kim","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute of Chemical Biology Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A.","family":"Sulikowski","sequence":"additional","affiliation":[{"name":"Department of Chemistry Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt Institute of Chemical Biology Vanderbilt University  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5666-7232","authenticated-orcid":false,"given":"Allison S.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Chemistry Vanderbilt University  Nashville Tennessee USA"},{"name":"Vanderbilt Institute of Chemical Biology Vanderbilt University  Nashville Tennessee USA"},{"name":"Department of Biological Sciences 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