{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:49:08Z","timestamp":1791964148400,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","award":["DE\u2010SC0010666"],"award-info":[{"award-number":["DE\u2010SC0010666"]}],"id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2026,10,14]]},"abstract":"<jats:p>\n                    Recent work concerning the reaction mechanism of the molybdenum\u2010containing formate dehydrogenases is discussed, focusing on two alternate mechanisms of action for the enzyme involving either formation of CO\n                    <jats:sub>2<\/jats:sub>\n                    or bicarbonate as the immediate product of the reaction. On the basis of the pH dependence of the rate of reduction of enzyme by formate and the results of a recent GC\/MS study undertaken under single\u2010turnover conditions indicating that no\n                    <jats:sup>18<\/jats:sup>\n                    O from solvent H\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>18<\/jats:sup>\n                    O is incorporated into product CO\n                    <jats:sub>2<\/jats:sub>\n                    , it is concluded that bicarbonate cannot be formed in the course of the reaction, and that cysteine, once dissociated from the molybdenum, cannot be functioning as a base in the course of the reaction.\n                  <\/jats:p>","DOI":"10.1002\/cbic.70555","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:01:21Z","timestamp":1791309681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recent 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