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Extracellular catalytic prodrug activation offers a complementary strategy in which a pericellular catalyst activates a diffusible caged payload without requiring carrier internalization. This approach requires catalysts that retain activity under extracellular redox conditions and concentrate near cells through local binding environments. Here, we use albumin\u2013ruthenium conjugates (ARCs) to define how redox environment and secreted protein acidic and rich in cysteine (SPARC), an albumin\u2010binding extracellular matrix glycoprotein, shape extracellular catalyst persistence and local albumin association. ARCs uncaged alloc\u2010protected fluorescent and doxorubicin substrates at low micromolar concentrations with limited intrinsic cytotoxicity. Catalytic activity was attenuated under ambient oxygen but preserved under oxygen\u2010limited or antioxidant conditions, consistent with oxygen\/redox\u2010associated catalyst deactivation. ARC retained uncaging activity after SPARC capture and washing, indicating that SPARC association does not block catalyst accessibility. In cell\u2010based assays, SPARC\u2010expressing 4T1 and BT\u2010549 cells showed rapid albumin association, whereas low\u2010SPARC MCF10A cells exhibited weaker early association enhanced by exogenous SPARC. Fluorescence imaging, trypan blue quenching, and washed\u2010cell uncaging assays support a predominantly extracellular\/pericellular mechanism that does not require carrier internalization. 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