{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:40:42Z","timestamp":1792521642638,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K18275JP23K0611726K09651"],"award-info":[{"award-number":["JP24K18275JP23K0611726K09651"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemBioChem"],"published-print":{"date-parts":[[2026,10,28]]},"abstract":"<jats:p>\n                    The new sulfolipid\u2010like natural product tritonicysteinolic acid (TTC) was isolated from an extract of the marine bacterium\n                    <jats:italic>Tritonibacter<\/jats:italic>\n                    and exhibited inhibitory activity against PGAM5, a protein phosphatase that localizes in the inner mitochondrial membrane. The full stereochemistry of TTC was elucidated through total synthesis, thereby enabling the synthesis of various derivatives. Structure\u2010activity relationship (SAR) studies were conducted, which revealed that the derivatives exhibited higher inhibitory activity against PGAM5 phosphatase relative to the parent natural product.\n                  <\/jats:p>","DOI":"10.1002\/cbic.70571","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:30:04Z","timestamp":1792521004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolation of Tritonicysteinolic Acid From a Marine Bacterium and Its Evaluation as a PGAM5 Inhibitor"],"prefix":"10.1002","volume":"27","author":[{"given":"Mai","family":"Nakagawasai","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Organic Chemistry Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Egami","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Organic Chemistry Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6929-3438","authenticated-orcid":false,"given":"Hayato","family":"Nagano","sequence":"additional","affiliation":[{"name":"Department of Cell Regulation Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimito","family":"Kai","sequence":"additional","affiliation":[{"name":"Department of Cell Regulation Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1877-9705","authenticated-orcid":false,"given":"Keita","family":"Komine","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Organic Chemistry Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Takouda","sequence":"additional","affiliation":[{"name":"Department of Cell Regulation Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1636-4469","authenticated-orcid":false,"given":"Hayato","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Organic Chemistry Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5024-0614","authenticated-orcid":false,"given":"Yoshimasa","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Center for Medical Innovation Nagasaki University  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8359-8399","authenticated-orcid":false,"given":"Kohsuke","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Cell Regulation Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3346-3354","authenticated-orcid":false,"given":"Jun","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Organic Chemistry Graduate School of Biomedical Sciences Nagasaki University  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901823106"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.06.021"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.357509"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201642698"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201708191"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvy077"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2021.119045"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvy077"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.01.008"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2026.02.003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2026.01.075"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"6154","DOI":"10.1021\/ja050878w","article-title":"Heteronuclear Two\u2010Bond Correlation: Suppressing Heteronuclear Three\u2010Bond or Higher NMR Correlations while Enhancing Two\u2010Bond Correlations Even for Vanishing 2\n                  J\n                  \n                     CH","volume":"127","author":"Nyberg N. T.","year":"2005","journal-title":"Journal of the American Chemical Society"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0079\u20106832(71)90008\u20105"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol991201e"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.48.924"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.48.929"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol991201e"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.0c01701"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/178381"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20101999\u20103119"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00381a020"},{"key":"e_1_2_9_23_1","unstructured":"For HPLS analysis see the Supporting Information."},{"key":"e_1_2_9_24_1","unstructured":"The stereochemistry of 29 was confirmed based on Kusumi's method; for details see the Supporting Information."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c06863"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2011.01.005"}],"container-title":["ChemBioChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.70571","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbic.70571","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbic.70571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:30:06Z","timestamp":1792521006000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cbic.70571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,20]]},"references-count":25,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,10,28]]}},"alternative-id":["10.1002\/cbic.70571"],"URL":"https:\/\/doi.org\/10.1002\/cbic.70571","archive":["Portico"],"relation":{},"ISSN":["1439-4227","1439-7633"],"issn-type":[{"value":"1439-4227","type":"print"},{"value":"1439-7633","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,20]]},"assertion":[{"value":"2026-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70571"}}