{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:13:47Z","timestamp":1790421227373,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T00:00:00Z","timestamp":1367539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The first cell growth factor, nerve growth factor (NGF), was discovered by Rita Levi\u2010Montalcini (RLM) in the early 1950s. Originally identified as neurite outgrowth\u2010stimulating factor, later studies revealed that non\u2010neuronal cells, including immune cells, endothelial cells, cardiomyocytes, pancreatic beta cells, prostate epithelial and adipose tissue cells, were also targets for and\/or sources of NGF. Nerve growth factor is well recognised as mediating multiple biological phenomena, ranging from the neurotrophic through immunotrophic and epitheliotrophic to metabotrophic effects. Consequently, NGF and other members of the neurotrophin family are implicated in the pathogenesis of a large spectrum of neuronal and non\u2010neuronal diseases, ranging from Alzheimer's and other neurodegenerative diseases to atherosclerosis and cardiometabolic disorders. Recent studies have demonstrated the therapeutic potentials of NGF in these conditions, including ocular and cutaneous diseases. NGF TrkA receptor antagonists emerged as novel drugs for pain, prostate and breast cancer, melanoma and urinary bladder syndromes. Here, we briefly describe the \u2018unpredictable\u2019 ideogenesis of the discovery of NGF, a eureka in the neuroscience.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbin.10098","type":"journal-article","created":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T09:53:52Z","timestamp":1375782832000},"page":"761-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Homage to Rita Levi\u2010<scp>M<\/scp>ontalcini, the queen of modern neuroscience"],"prefix":"10.1002","volume":"37","author":[{"given":"Luigi","family":"Aloe","sequence":"first","affiliation":[{"name":"Institute of Cell Biology and Neurobiology National Research Council (CNR) Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George N.","family":"Chaldakov","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Biology Medical University Varna Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/REVNEURO.1993.4.1.41"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.14748\/bmr.v10.1"},{"key":"e_1_2_9_4_1","first-page":"1","article-title":"NGF and related molecules in healthy and disease","volume":"146","author":"Aloe L","year":"2004","journal-title":"Prog Brain Res, Vol."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(77)90772-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.22.10440"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916939409009542"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479\u20105876\u201010\u2010239"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.3.695"},{"key":"e_1_2_9_10_1","first-page":"354","article-title":"Effect of topical application of nerve growth factor on pressure ulcers","volume":"307","author":"Bernabei R","year":"1999","journal-title":"Lancet"},{"key":"e_1_2_9_11_1","first-page":"257","article-title":"The metabotrophic NGF and BDNF: an emerging concept","volume":"149","author":"Chaldakov G","year":"2011","journal-title":"Arch Ital Biol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.14748\/bmr.v13.119"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(03)46018-4"},{"key":"e_1_2_9_14_1","first-page":"79","article-title":"NGF and BDNF: from nerves to adipose tissue, from neurokines to metabokines. 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Raffaello Cortina Editore."},{"key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1073\/pnas.46.3.373","article-title":"Excessive growth of the sympathetic ganglia evoked by a protein isolated from the mouse salivary glands","volume":"46","author":"Levi\u2010Montalcini R","year":"1960","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401160206"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930400016717"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31821b1ac5"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.210088"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21022"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476\u20104598\u20109\u2010157"},{"key":"e_1_2_9_39_1","first-page":"179","article-title":"Adipose tissue\u2010derived nerve growth factor and brain\u2010derived neurotrophic factor: results from experimental stress and diabetes","volume":"28","author":"Sornelli F","year":"2009","journal-title":"Gen Physiol Biophys"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.21"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0045(20001001)45:2<140::AID-PROS8>3.0.CO;2-#"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbin.10098","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.10098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T22:42:23Z","timestamp":1696632143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.10098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,3]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1002\/cbin.10098"],"URL":"https:\/\/doi.org\/10.1002\/cbin.10098","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,3]]},"assertion":[{"value":"2013-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-05-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}