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Although the pan\u2010caspase inhibitor, Z\u2010VAD\u2010fmk, did not inhibit genistein\u2010induced apoptosis, release of apoptosis\u2010inducing factor (AIF) into the cytosol occurred. Poly\u2010ADP ribose polymerase inhibition also abrogated genistein\u2010induced apoptosis. Genistein decreased nuclear p65 translocation and I\u03baB\u03b1 phosphorylation, and downregulated the anti\u2010apoptotic proteins, XIAP, cIAP and survivin, NF\u2010\u03baB\u2010responsive gene products. Thus, genistein is a promising agent for ATL that induces caspase\u2010independent apoptosis through inhibition of the NF\u2010\u03baB pathway.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbin.10101","type":"journal-article","created":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T09:54:05Z","timestamp":1375782845000},"page":"742-747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Genistein induces apoptotic cell death associated with inhibition of the <scp>NF<\/scp>\u2010\u03baB pathway in adult T\u2010cell leukemia cells"],"prefix":"10.1002","volume":"37","author":[{"given":"Masao","family":"Yamasaki","sequence":"first","affiliation":[{"name":"Faculty of Agriculture, Department of Biochemistry and Applied Biosciences University of Miyazaki 1\u20101 Gakuenkibanadai\u2010nishi Miyazaki 889\u20102192 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