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Willemite (Zn<jats:sub>2<\/jats:sub>SiO<jats:sub>4<\/jats:sub>) ceramics were prepared and coated on the surface of electrospun fabricated scaffolds. After scaffolds and nanoparticles characterization, osteoconductivity of the construct was analyzed using digital mammography, multislice spiral\u2010computed tomography (MSCT) imaging, and histological analysis. Eight weeks after implantation, no sign of inflammation was observed at the site of the osseous defect. The results showed that the ceramics supported bone regeneration and highest bone reconstruction were observed in willemite\u2010coated PLGA. This suggests that electrospun PLGA nanofibers coated with BG are potential candidate implants for bone tissue engineering applications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbin.10318","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T09:35:27Z","timestamp":1402047327000},"page":"1271-1279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Coating of electrospun poly(lactic\u2010co\u2010glycolic acid) nanofibers with willemite bioceramic: improvement of bone reconstruction in rat model"],"prefix":"10.1002","volume":"38","author":[{"given":"Fatemeh","family":"Jamshidi Adegani","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetic Engineering Stem Cell Technology Research Center Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lida","family":"Langroudi","sequence":"additional","affiliation":[{"name":"Department of 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