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The fibril precursors of IAPP contribute to its cytotoxicity on pancreatic \u03b2 cells and be important in causing \u03b2\u2010cell dysfunction in T2DM. However, the development of effective this study, inhibitors against the toxicity of IAPP has been extremely challenging. We have found that pre\u2010incubation with geniposide dose\u2010dependently prevented human IAPP (hIAPP)\u2010induced cell damage in INS\u20101E cells, and bacitracin, an inhibitor of IDE activity, prevented significantly the protective effects of geniposide in pancreatic INS\u20101E cells significantly. Geniposide induced the expression of insulin\u2010degrading enzyme (IDE), a key degrading protein of hIAPP, but had no significant effect on the aggregation of hIAPP. These findings indicate that geniposide prevents hIAPP\u2010induced cytotoxicity in INS\u20101E cells involving upregulation of IDE expression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbin.10394","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T08:58:22Z","timestamp":1413449902000},"page":"373-378","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Geniposide protects pancreatic INS\u20101E \u03b2 cells from hIAPP\u2010induced cell damage: Potential involvement of insulin degrading\u2010enzyme"],"prefix":"10.1002","volume":"39","author":[{"given":"Yonglan","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Pharmacy and Bioengineering Chongqing University of Technology Chongqing 400054 China"},{"name":"Chongqing Key Lab of Catalysis and Functional Organic Molecules Chongqing Technology and Business University Chongqing 400067 China"},{"name":"College of 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