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To attenuate disease severity, drug development studies have been applied mainly to target the <jats:italic>Survival of Motor Neuron 2 (SMN2)<\/jats:italic> gene, which is an important modifier of SMA. Although several compounds have been tested, there is still no cure for SMA. In this study, SMN2\u2010inducing effects of quercetin, an abundant flavonoid polyphenol in human diet, was investigated in the fibroblast cell lines of two SMA type I patients. 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