{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:49:07Z","timestamp":1767988147165,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,20]],"date-time":"2015-01-20T00:00:00Z","timestamp":1421712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Guangxi Province postgraduate scientific research and innovation projects","award":["YCSZ2014102"],"award-info":[{"award-number":["YCSZ2014102"]}]},{"name":"Guangxi Natural Science Foundation of China Grant","award":["2013GXNSFAA019135"],"award-info":[{"award-number":["2013GXNSFAA019135"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Systemic sclerosis (SSc) is a connective tissue disease characterized by fibrosis of the skin and internal organs. Th17 cells and interleukin\u201017 (also called IL\u201017A) have been found to be increased in peripheral blood and skin in patients with SSc. IL\u201021 is a potent inducer of Th17 differentiation that is produced by activated T cells, and whose relationship with Th17 cells in SSc is unclear. Here, using a bleomycin (BLM)\u2010induced mouse model of skin fibrosis, we detected the frequency of CD4+\/IL\u201017+ (Th17) cells, CD4+\/IL\u201021+ T cells and IL\u201021+ Th17 cells in peripheral blood, skin and lungs, as well as the serum content of IL\u201017A and IL\u201021. In addition, we assessed the differentiation of CD4+ T cells cultured from these mice into Th17 cells in response to treatment with IL\u201021. Compared with the control mice, Th17 cell counts and IL\u201017A levels were significantly increased and correlated with inflammatory and fibrotic indices in the skin and lungs of the BLM\u2010induced fibrosis mice. Moreover, serum levels of CD4+\/IL\u201021+ T cells, IL\u201021+ Th17 cells, and IL\u201021 were significantly increased in these mice, and correlated positively with serum levels of Th17 cells. In vitro experiments showed that IL\u201021 treated CD4+ T cells derived from BLM\u2010induced mice differentiated into Th17 cells. Our results indicate that Th17 cells and IL\u201017A contributes to inflammatory and fibrotic processes in the skin and lungs in a BLM\u2010induced mouse model of SSc. Moreover, the expansion of the Th17 cell population may be subsequent to IL\u201021 promotion of the differentiation of CD4+ T cells in these mice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbin.10410","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T18:14:37Z","timestamp":1418148877000},"page":"388-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["IL\u201021 induction of CD4+ T cell differentiation into Th17 cells contributes to bleomycin\u2010induced fibrosis in mice"],"prefix":"10.1002","volume":"39","author":[{"given":"Ling","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Ning","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of 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