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Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S), a member of the gas transmitter family, performs important biological actions, including protection against cardiovascular diseases and maintenance of the lipid metabolism equilibrium in hepatocytes and adipocytes. In this study, we investigated the possible molecular mechanism of H<jats:sub>2<\/jats:sub>S that influences apolipoprotein(a) [apo(a)] biosynthesis. We also determined the effects of H<jats:sub>2<\/jats:sub>S on apo(a) expression and secretion in HepG2 cells as well as the underlying mechanisms. Results showed that H<jats:sub>2<\/jats:sub>S significantly inhibited the expression and secretion levels of apo(a). These effects were attenuated by the PKC\u03b1 inhibitor and FXR siRNA. H<jats:sub>2<\/jats:sub>S also reduced HNF4\u03b1 expression and enhanced FXR expression. The Akt inhibitor partially reversed H<jats:sub>2<\/jats:sub>S\u2010induced inhibition of apo(a) and HNF4\u03b1 expression and apo(a) secretion. This study reveals that H<jats:sub>2<\/jats:sub>S suppressed apo(a) expression and secretion via the PKC\u03b1\u2010FXR and PI3K\/Akt\u2010HNF4\u03b1 pathways.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbin.10632","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T07:18:38Z","timestamp":1465888718000},"page":"906-916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["H<sub>2<\/sub>S inhibits apo(a) expression and secretion through PKC\u03b1\/FXR and Akt\/HNF4\u03b1 pathways in HepG2 cells"],"prefix":"10.1002","volume":"40","author":[{"given":"Kai","family":"Qu","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Research Key Laboratory for Atherosclerology of Hunan Province University of South China Hengyang Hunan 421001 PR 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