{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T09:24:55Z","timestamp":1769937895406,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Osteoarthritis (OA) is a chronic disease pathologically characterized by articular cartilage degeneration and damage. Currently, studies have found that circular RNA (circRNA) is involved in intracellular RNA regulating network and is closely related to the occurrence and development of diseases, therefore it may become a new biological marker and therapeutic target. After stimulating chondrocytes with interleukin\u20101 beta (IL\u20101\u03b2), hsa_circ_0005105 expression was significantly upregulated, while miR\u201026a expression was significantly inhibited. Hsa_circ_0005105 did not influence miR\u201026a expression but inhibited its transcriptional activity so as to upregulate the expression of its target NAMPT. Studies further indicated that hsa_circ_0005105 can inhibit the expression of type II collagen and aggrecan, promote the expression of MMP\u201013 and ADAMTS\u20104, and the generation of PGE2, IL\u20106, and IL\u20108, but the linear sequence of hsa_circ_0005105 cannot. MiR\u201026a has the opposite effect, and hsa_circ_0005105 can antagonize the function of miR\u201026a. When NAMPT expression was downregulated, the above function of hsa_circ_0005105 was significantly weakened. Therefore, hsa_circ_0005105 can promote extracellular matrix (ECM) degradation by regulating the expression of miR\u201026a target NAMPT. These findings will provide new targets for treatment and prevention of OA and other orthopedic diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbin.10761","type":"journal-article","created":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T04:57:33Z","timestamp":1489035453000},"page":"1283-1289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["CircRNA hsa_circ_0005105 upregulates NAMPT expression and promotes chondrocyte extracellular matrix degradation by sponging miR\u201026a"],"prefix":"10.1002","volume":"41","author":[{"given":"You","family":"Wu","sequence":"first","affiliation":[{"name":"Institute of Traumatic Orthopaedics of PLA Medical Center of Assessment, Prevention and Treatment of Bone &amp; Joint Diseases; Guangdong Key Laboratory of Orthopaedic Technology and Implant Materials; Key Laboratory of Trauma &amp; Tissue Repair of Tropical Area of PLA, Hospital of Orthopaedics, Guangzhou General Hospital of Guangzhou Military Command Guangzhou Guangdong 510010 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Traumatic Orthopaedics of PLA Medical Center of Assessment, Prevention and Treatment of Bone &amp; Joint Diseases; Guangdong Key Laboratory of Orthopaedic Technology and Implant Materials; Key Laboratory of Trauma &amp; Tissue Repair of Tropical Area of PLA, Hospital of Orthopaedics, Guangzhou General Hospital of Guangzhou Military Command Guangzhou Guangdong 510010 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Spine Surgery Hospital of Orthopaedics, Guangzhou General Hospital of Guangzhou Military Command Guangzhou Guangdong 510010 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Neurosurgery Hospital of Orthopaedics, Guangzhou General Hospital of Guangzhou Military Command Guangzhou Guangdong 510010 P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.11005\/jbm.2016.23.3.121"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22833"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002267"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389202916666150707161554"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2016-103758"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep21499"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.02.014"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30338"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23431"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11993"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003740"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.196"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2016.09.011"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1735"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22572"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03702"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2008.02.001"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbw045"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1999.0266"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2007.02167.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10564"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1788"},{"key":"e_1_2_6_24_1","first-page":"1","article-title":"The emerging landscape of circular RNA in life processes","volume":"11","author":"Qu S","year":"2016","journal-title":"RNA Biol"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2016.02.003"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2016.1226515"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.183426"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2016.08.011"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/561459"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20150071"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbin.10761","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.10761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T21:05:41Z","timestamp":1696712741000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.10761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,11]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/cbin.10761"],"URL":"https:\/\/doi.org\/10.1002\/cbin.10761","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,11]]},"assertion":[{"value":"2016-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-04-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}