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In this cellular process, the hepatic stellate cells (HSCs) support the organ fibrogenesis. The HSCs are found in two distinct morpho\u2010physiological states: quiescent and activated. In normal liver, most HSCs are found in quiescent state, presenting a considerable amount of lipid droplets in the cytoplasm, while in injured liver, the activated phenotype of HSCs is a myofibroblast, that secrete extracellular matrix elements and contribute to the establishment of the fibrotic process. Studies on the molecular mechanisms by which HSCs try to restore their quiescent state have been performed; however, no effective treatment to reverse fibrosis has been so far prescribed. Therefore, the elucidation of the cellular and molecular mechanisms of apoptosis, senescence, and the cell reversion phenotype process from activate to quiescent state will certainly contribute to the development of effective therapies to treat hepatic fibrosis. In this context, this review aimed to address central elements of apoptosis, senescence, and reversal of HSC phenotype in the control of hepatic fibrogenesis, as a guide to future development of therapeutic strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbin.10790","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T13:48:26Z","timestamp":1494596906000},"page":"946-959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Molecular interplays in hepatic stellate cells: apoptosis, senescence, and phenotype reversion as cellular connections that modulate liver fibrosis"],"prefix":"10.1002","volume":"41","author":[{"given":"Brenda","family":"de Oliveira da Silva","sequence":"first","affiliation":[{"name":"Universidade Federal de Ouro Preto N\u00facleo de Pesquisa em Ci\u00eancias Biol\u00f3gicas Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Biotecnologia Ouro Preto Minas Gerais Brazil"},{"name":"Molecular Biology Laboratory Departamento de Biologia Instituto de Bioci\u00eancias Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d\u2212Campus Rio Claro Rio Claro S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Ferrreira","family":"Ramos","sequence":"additional","affiliation":[{"name":"Molecular Biology Laboratory Departamento de Biologia Instituto de Bioci\u00eancias Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d\u2212Campus Rio Claro Rio Claro S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen C. 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