{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:28:54Z","timestamp":1773923334006,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T00:00:00Z","timestamp":1506643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2009\/16150\u20106"],"award-info":[{"award-number":["2009\/16150\u20106"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>In this commentary, we propose a relationship between desquamation, initially described as the collective detachment and deletion of epithelial cell in the prostate gland after castration, and proliferative inflammatory atrophy (PIA) and stromal growth in benign prostate hyperplasia (BPH). First, in response to diverse stimuli, including inflammatory mediators, epithelial cells desquamate and leave a large surface of the luminal side of the basement membrane (BM) exposed. Basal cells are activated into intermediate\u2010type cells, which change morphology to cover and remodel the exposed BM (simple atrophy) to a new physiological demand (such as in the hypoandrogen environment, simulated by surgical and\/or chemical castration) and\/or to support re\u2010epithelialization (under normal androgen levels). In the presence of inflammation (that might be the cause of desquamation), the intermediate\u2010type cells proliferate and characterize PIA. Second, in other circumstances, desquamation is an early step of epithelial\u2010to\u2010mesenchymal transition (EMT), which contributes to stromal growth, as suggested by some experimental models of BPH. The proposed associations correlate unexplored cell behaviors and reveal the remarkable plasticity of the prostate epithelium that might be at the origin of prostate diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbin.10867","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T16:46:37Z","timestamp":1504716397000},"page":"1265-1270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Desquamation takes center stage at the origin of proliferative inflammatory atrophy, epithelial\u2013mesenchymal transition, and stromal growth in benign prostate hyperplasia"],"prefix":"10.1002","volume":"41","author":[{"given":"Danilo","family":"Ferrucci","sequence":"first","affiliation":[{"name":"Department of Structural and Functional Biology, Institute of Biology State University of Campinas (UNICAMP) Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel F.","family":"Biancardi","sequence":"additional","affiliation":[{"name":"Department of Histology, Embryology, and Cell Biology, Institute of Biological Sciences Federal University of Goi\u00e1s Goiania GO Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umar","family":"Nishan","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Centre in Biomedical Materials (IRCBM) COMSATS Institute of Information Technology Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafaela","family":"Rosa\u2010Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology, Institute of Biology State University of Campinas (UNICAMP) Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hernandes F.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology, Institute of Biology State University of Campinas (UNICAMP) Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812666106"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2010.01.010"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.01.081"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.23886"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/cbir.1996.0104"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10831"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.96.6.1662"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00307300"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65517-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2090"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2004-0033"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.2990150304"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20905"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.2.5683"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.3.8603596"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2010.06.009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5320(72)90112-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2009.00963.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39104"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.04164"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02889300"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811295106"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004419900057"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905524107"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb02734.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021562"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05698"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1522"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.01.043"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2600"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-013-1152-3"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097080"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.4777"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1793-9"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2014.04.005"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64814-6"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.20.2371"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27179"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20533"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.8.1905"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35273-4"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070300407"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64286-1"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.07.003"},{"key":"e_1_2_7_46_1","first-page":"340","article-title":"Lineage analysis of basal epithelial cells reveals their unexpected plasticity and supports a cell\u2010of\u2010origin model for prostate cancer heterogeneity","volume":"64","author":"Wang Z","year":"2013","journal-title":"Nat Cell Biol"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.175"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbin.10867","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.10867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T14:32:41Z","timestamp":1695997961000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.10867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,29]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1002\/cbin.10867"],"URL":"https:\/\/doi.org\/10.1002\/cbin.10867","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,29]]},"assertion":[{"value":"2017-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}