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Since then, research efforts to elucidate the role of MCU and its regulatory elements in different biological models have multiplied. MCU is the pore\u2010forming subunit of a multimeric complex (the MCU complex or MCUC) and its predicted structure in trypanosomes is simpler than in mammalian cells, lacking two of its subunits and probably possessing other unidentified components. MCU protein has been characterized in <jats:italic>Trypanosoma brucei<\/jats:italic> and <jats:italic>Trypanosoma cruzi<\/jats:italic>, the causative agents of African and American trypanosomiasis, respectively. Contrary to its mammalian homolog, TbMCU was found to be essential for cell growth and survival, while its paralog MCUb is an essential protein in <jats:italic>T. cruzi<\/jats:italic>. These findings could be further exploited for chemotherapeutic purposes. The emergence of new molecular tools for the genetic manipulation of trypanosomatids has been determinant for the functional characterization of the MCUC components in these organisms. However, further research has to be done to determine the role of each component in intracellular calcium signaling and cell bioenergetics. In this mini\u2010review we summarize the original results on mitochondrial calcium uptake in trypanosomes, how did they contribute to the molecular identification of the MCU, and the functional characterization of the MCUC subunits that has so far been studied in these peculiar eukaryotes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbin.10928","type":"journal-article","created":{"date-parts":[[2017,12,29]],"date-time":"2017-12-29T12:02:35Z","timestamp":1514548955000},"page":"656-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The mitochondrial calcium uniporter complex in trypanosomes"],"prefix":"10.1002","volume":"42","author":[{"given":"Noelia","family":"Lander","sequence":"first","affiliation":[{"name":"Departamento de Patologia Cl\u00ednica Faculdade de Ci\u00eancias M\u00e9dicas Universidade Estadual de Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A.","family":"Chiurillo","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Cl\u00ednica Faculdade de Ci\u00eancias M\u00e9dicas Universidade Estadual de Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayara S.","family":"Bertolini","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Cl\u00ednica Faculdade de Ci\u00eancias M\u00e9dicas Universidade Estadual de Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Docampo","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Cl\u00ednica Faculdade de Ci\u00eancias M\u00e9dicas Universidade Estadual de Campinas Campinas S\u00e3o Paulo Brazil"},{"name":"Center for Tropical and Emerging Global Diseases University of Georgia Athens Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An\u00edbal E.","family":"Vercesi","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Cl\u00ednica Faculdade de Ci\u00eancias M\u00e9dicas Universidade Estadual de Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10234"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(90)90008-A"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2728(70)90057-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00574-17"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.028"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10230"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.47.11.1744"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2011.10.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3101005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31229-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(89)90202-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2014.09.001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-13-556"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1216955110"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3865"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201643748"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.749655"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01012-15"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.07.011"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2622"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00139"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"6020","DOI":"10.1016\/S0021-9258(18)42656-7","article-title":"Calcium homeostasis in procyclic and bloodstream forms of Trypanosoma brucei. 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