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They are fragmented, round, and small. Despite these characteristics suggesting that they are inactive, there is accumulating evidence that mitochondrial dysfunctions are a major cause of infertility and generation of aneuploidies in humans. In addition, mitochondria and their own genomes (mitochondrial DNA\u2014mtDNA) may become damaged with time, which might be one reason why aging leads to infertility. As a result, mitochondria have been proposed as an important target for evaluating oocyte and embryo quality, and developing treatments for female infertility. On the other hand, mutations in mtDNA may cause mitochondrial dysfunctions, leading to severe diseases that affect 1 in 4,300 people. Moreover, very low levels of mutated mtDNA seem to be present in every person worldwide. These may increase with time and associate with late\u2010onset degenerative diseases such as Parkinson disease, Alzheimer disease, and common cancers. Mutations in mtDNA are transmitted down the maternal lineage, following a poorly understood pattern of inheritance. Recent findings have indicated existence in the female germline of a purifying filter against deleterious mtDNA variants. Although the underlying mechanism of this filter is largely unknown, it has been suggested to rely on autophagic degradation of dysfunctional mitochondria or selective replication\/transmission of non\u2010deleterious variants. Thus, understanding the mechanisms regulating mitochondrial inheritance is important both to improve diagnosis and develop therapeutic tools for preventing transmission of mtDNA\u2010encoded diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cbin.10947","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T06:22:42Z","timestamp":1518070962000},"page":"711-724","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The role of mitochondria in the female germline: Implications to fertility and inheritance of mitochondrial diseases"],"prefix":"10.1002","volume":"42","author":[{"given":"Marcos Roberto","family":"Chiaratti","sequence":"first","affiliation":[{"name":"Departamento de Gen\u00e9tica e Evolu\u00e7\u00e3o Universidade Federal de S\u00e3o Carlos S\u00e3o Carlos SP 13565\u2010905 Brazil"},{"name":"Faculdade de Medicina Veterin\u00e1ria e Zootecnia Universidade de 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