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Beyond the classical cholesterol risk factor, other conditions such as oxidative stress are well documented to promote atherosclerosis. The<jats:italic>Mangifera indica<\/jats:italic>L. extract (Vimang\u00ae) was reported to present antioxidant and hypocholesterolemic properties. Thus, here we evaluate the effects of Vimang treatment on risk factors of the atherosclerosis prone model of familial hypercholesterolemia, the LDL receptor knockout mice. Mice were treated with Vimang during 2 weeks and were fed a cholesterol\u2010enriched diet during the second week. The Vimang treated mice presented significantly reduced levels of plasma (15%) and liver (20%) cholesterol, increased plasma total antioxidant capacity (10%) and decreased reactive oxygen species (ROS) production by spleen mononuclear cells (50%),<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 for all. In spite of these benefits, the average size of aortic atherosclerotic lesions stablished in this short experimental period did not change significantly in Vimang treated mice. Therefore, in this study we demonstrated that Vimang has protective effects on systemic and tissue\u2010specific risk factors, but it is not sufficient to promote a reduction in the initial steps of atherosclerosis development. In addition, we disclosed a new antioxidant target of Vimang, the spleen mononuclear cells that might be relevant for more advanced stages of atherosclerosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbin.10950","type":"journal-article","created":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T11:23:12Z","timestamp":1518261792000},"page":"747-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>Mangifera indica<\/i>L. extract (Vimang\u00ae) reduces plasma and liver cholesterol and leucocyte oxidative stress in hypercholesterolemic LDL receptor deficient mice"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6566-4244","authenticated-orcid":false,"given":"Gabriel G.","family":"Dorighello","sequence":"first","affiliation":[{"name":"Department of Structural and Functional Biology Biology Institute State University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia M.","family":"Inada","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Department of Clinical Pathology State University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno A.","family":"Paim","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Department of Clinical Pathology State University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto L.","family":"Pardo\u2010Andreu","sequence":"additional","affiliation":[{"name":"Centro de Estudio para las Investigaciones y Evaluaciones Biol\u00f3gicas Instituto de Farmacia y Alimentos de La Universidad de La Habana La Habana Cuba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anibal E.","family":"Vercesi","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Department of Clinical Pathology State University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0119-6992","authenticated-orcid":false,"given":"Helena C.F.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology Biology Institute State University of Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(01)00361-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)33877-3"},{"key":"e_1_2_8_4_1","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood. 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