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In this work, miR\u2010378 expression in melanoma and in adjacent non\u2010cancerous tissue was evaluated with a quantitative real\u2010time polymerase chain reaction. A series of assays (wound healing, Transwell, and nude mouse subcutaneous tumor model) were used to investigate the implications of abnormal miR\u2010378 regulation on melanoma cell migration and invasion in vitro, and on tumorigenicity in vivo. Prediction and conformation of the miR\u2010378 target gene was undertaken using bioinformatic analysis and luciferase reporter system. Expression of miR\u2010378 was often increased in melanoma, and shown to potentiate its migration, invasion, and tumorigenicity. miR\u2010378 acted, at least partially, through inhibition of the potential target FOXN3 and via Wnt\/\u03b2\u2010catenin pathway activation. The findings indicate that miR\u2010378 triggers melanoma development and progression. This miRNA could be a novel diagnostic and prognostic biological marker and provide utility for targeted treatment of melanoma.<\/jats:p>","DOI":"10.1002\/cbin.11027","type":"journal-article","created":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T12:02:05Z","timestamp":1530705725000},"page":"1113-1124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["MicroRNA\u2010378 regulates epithelial\u2013mesenchymal transition and metastasis of melanoma by inhibiting FOXN3 expression through the Wnt\/\u03b2\u2010catenin pathway"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9682-4586","authenticated-orcid":false,"given":"Mengyao","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shaanxi 710004 P. R. 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