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At the same time, tumors have become the main disease that endangers human health. In recent years, a large number of researchers have explored the relationship between lncRNA and tumors. HOXA11\u2010AS is one of these lncRNAs. The long non\u2010coding RNA HOXA11 antisense RNA (HOXA11\u2010AS) is a novel lncRNA recently discovered. It is found in a variety of tumors such as ovarian cancer, glioma, and gastric cancer (GC) and so on, and is defined as an oncogene. It promotes tumor proliferation and metastasis by interacting with proteins such as miRNA and EZH2. In this paper, we review the mechanism of interaction between HOXA11\u2010AS and various tumors in recent years, and believe that it can be a potential tumor marker and therapeutic target in the future prevention and treatment of tumors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbin.11045","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T11:31:30Z","timestamp":1533900690000},"page":"1596-1601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The role of the long non\u2010coding RNA HOXA11\u2010AS in promoting proliferation and metastasis of malignant tumors"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9569-3644","authenticated-orcid":false,"given":"Shounan","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery The Second Affiliated Hospital of Harbin Medical University Harbin 150086 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