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In this study, miR\u2010122 was overexpressed in ovarian cancer cells, and phenotypic experiments demonstrated that miR\u2010122 inhibited migration and invasion in SKOV3 and OVCAR3 cells. MiR\u2010122 also suppressed epithelial mesenchymal transition (EMT), evidenced by expression changes of E\u2010cadherin, vimentin, matrix metalloproteinase (MMP)2, and MMP14. Prolyl\u20104\u2010hydroxylase subunit alpha\u20101 (P4HA1) was identified as a target of miR\u2010122, and downregulated by miR\u2010122. MiR\u2010122\u2010induced the elevation of migration, invasion, and EMT were recovered by P4HA1. Additionally, miR\u2010122 restrained the tumor metastasis of SKOV3 cells in peritoneal cavity of nude mice. In summary, we demonstrated that miR\u2010122 inhibited migration, invasion, EMT, and metastasis in peritoneal cavity of ovarian cancer cells by targeting P4HA1 for the first time, which shed lights on the discovery of miR\u2010122 and P4HA1 as possible potential diagnostic markers and therapeutic targets for ovarian cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbin.11052","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T11:15:08Z","timestamp":1535022908000},"page":"1564-1574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["MiR\u2010122 inhibits epithelial mesenchymal transition by regulating P4HA1 in ovarian cancer cells"],"prefix":"10.1002","volume":"42","author":[{"given":"Yanan","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Gynecology The Fourth Hospital of Hebei Medical University Shijiazhuang 050011 People's Republic of 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