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More recently, the heptapeptide angiotensin\u2010(1\u20107) [ang\u2010(1\u20107)] was reported to be able to modulate liver fibrosis and even steatosis; however, the molecular bases of these effects are not clear. In this study, we investigated the overexpression of the microRNA\u20101254 in the human hepatic stellate cell line LX\u20102, based on the effect of the heptapeptide in such cells, previously, demonstrated by our research group. In addition, this miRNA was chosen based on the identification of putative binding site of this small molecule in the mRNA sequences of different molecular connectors of the AKT\/ PI3K pathway, which is modulated by the heptapeptide and connects to the control of several cellular mechanisms, including proliferation, survival, migration, and even liver fibrogenesis. The results revealed an innovative function of the miR\u20101254 in controlling SMAD3 and pro\u2010fibrosing elements as well as the wound healing response in LX\u20102, attenuating the scaring repair of the injured tissue. The combined findings provide useful information for future studies on the controlling of hepatic fibrogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbin.11075","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T12:40:32Z","timestamp":1542976832000},"page":"333-343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["MicroRNA\u20101254 contributes to the controlling of pro\u2010fibrogenic environment in LX\u20102 cells by modulating SMAD3 and wound repair: new insights in hepatic fibrosis"],"prefix":"10.1002","volume":"43","author":[{"given":"Let\u00edcia Rocha","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular, Departamento de Biologia Instituto de Bioci\u00eancias, Universidade Estadual Paulista \u201cJ\u00falio de Mesquita Filho\u201d \u2212 Campus Rio Claro Rio Claro SP 13506\u2010900 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