{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:54:49Z","timestamp":1767909289780,"version":"3.49.0"},"reference-count":61,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 81570638"],"award-info":[{"award-number":["No. 81570638"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Peritoneal dialysis (PD) is often used to treat patients with end stage renal disease, and its long\u2010term complications include excessive inflammation and oxidative stress. Allograft inflammatory factor 1 (AIF\u20101), as a cytoplasmic protein, is originally identified from infiltrating macrophages, and it was associated with inflammation in the cells other than macrophages, such as endothelial cells and vascular smooth muscle cells. To clarify the molecular mechanisms of AIF\u20101\u2010modulated pathological changes in the peritoneum during PD, we first detected the AIF\u20101 expression in peritoneal tissues from PD mice. Results revealed that the pro\u2010fibrotic stimulation caused AIF\u20101 upregulation and triggered inflammation in peritoneal tissues, and that AIF\u20101 co\u2010expressed with pan\u2010cytokeratin (a marker of peritoneal mesothelial cells). We next treated primary mouse peritoneal mesothelial cells (pan\u2010cytokeratin and intercellular adhesion molecule 1 positive cells) with 50 or 100\u2009ng\/mL recombinant AIF\u20101, and evaluated the direct effects of AIF\u20101 on these cells in vitro. We found that exogenous AIF\u20101 treatment induced inflammation and oxidative stress in mesothelial cells. Apart from the augmented IL\u20106 and TNF\u2010\u03b1 secretion, the level of ROS was upregulated and the activity of anti\u2010oxidative SOD was reduced in cells exposed to AIF\u20101. Moreover, AIF\u20101 simulation triggered the activation of NF\u2010\u03baB pathway\u2014enhanced the conversion of I\u03baB to phosphorylated I\u03baB and promoted the translocation of NF\u2010\u03baB p65 from cytoplasm into nucleus. Additionally, AIF\u20101\u2010evoked inflammation in peritoneal mesothelial cells was attenuated by the addition of NF\u2010\u03baB inhibitor (BAY 11\u20137082). In brief, this study provides us novel information to understand the molecular regulation mechanisms of AIF\u20101 in peritoneal fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cbin.11115","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T07:14:40Z","timestamp":1550128480000},"page":"495-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Role of allograft inflammatory factor\u20101 in the regulation of inflammation and oxidative stress in primary peritoneal mesothelial cells"],"prefix":"10.1002","volume":"43","author":[{"given":"Yinan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Harbin Medical University Harbin 150001 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Harbin Medical University Harbin 150001 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueying","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Harbin Medical University Harbin 150001 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lirong","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Harbin Medical University Harbin 150001 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,12]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"511","article-title":"[Role of allograft inflammatory factor\u20101 in regulating the proliferation, migration and apoptosis of colorectal cancer cells]","volume":"38","author":"Ai XL","year":"2018","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200009000-00008"},{"key":"e_1_2_7_4_1","first-page":"71","article-title":"Cardiac and renal fibrosis and oxidative stress balance in lipopolysaccharide\u2010induced inflammation in male rats","volume":"14","author":"Asgharzadeh F","year":"2018","journal-title":"ARYA Atheroscler"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2010.00234"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-00427"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.163"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.25.13879"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2011.01.006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2012.00286"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2013.00286"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02430-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010000233"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.2003.00476.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2014.00038"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/089686089201200105","article-title":"Pathogenesis of peritoneal fibrosing syndromes (sclerosing peritonitis) in peritoneal dialysis","volume":"12","author":"Dobbie JW","year":"1992","journal-title":"Perit Dial Int"},{"key":"e_1_2_7_17_1","first-page":"3","article-title":"Categorization of ultrastructural changes in peritoneal mesothelium, stroma and blood vessels in uremia and CAPD patients","volume":"6","author":"Dobbie JW","year":"1990","journal-title":"Adv Perit Dial"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/003693308102600305"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfi159"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30159"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2013.00089"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0293-137"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011060607"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1139\/H07-098"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2009.01162.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2011.00270"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14509"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-007-0474-7"},{"key":"e_1_2_7_29_1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1177\/089686080702700413","article-title":"Impact of ACE inhibitors and AII receptor blockers on peritoneal membrane transport characteristics in long\u2010term peritoneal dialysis patients","volume":"27","author":"Kolesnyk I","year":"2007","journal-title":"Perit Dial Int"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn421"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2012.01.023"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.101980"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-002-0441-0"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.12.035"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070885"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415021000033767"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1800255115"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489952"},{"key":"e_1_2_7_39_1","first-page":"78","article-title":"Peritoneal rest may successfully recover ultrafiltration in patients who develop peritoneal hyperpermeability with time on continuous ambulatory peritoneal dialysis","volume":"18","author":"Rodrigues A","year":"2002","journal-title":"Adv Perit Dial"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050964"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2010.00604.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05836-6"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.156794"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.07.095"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230719"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00334.2006"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00325.2008"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/750602"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118003"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199605150-00018"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01301.x"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2010.10.015"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.2177\/jsci.37.139"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20180240"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020809"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh316"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-018-4190-y"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.06.138"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.09.087"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2013.07.008"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000188139.11931.98"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.03.040"}],"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbin.11115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbin.11115","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbin.11115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T11:46:27Z","timestamp":1694346387000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbin.11115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,12]]},"references-count":61,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1002\/cbin.11115"],"URL":"https:\/\/doi.org\/10.1002\/cbin.11115","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,12]]},"assertion":[{"value":"2018-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}