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The aim of this study was to evaluate the ability of the mRVG\u20109R peptide to deliver DNA molecules to murine brain cells. The mRVG\u20109R peptide, a karyophilic peptide (KP) and a plasmid encoding green fluorescent protein (<jats:italic>GFP<\/jats:italic>) were bound by electrostatic charges to form the mRVG\u20109R complex. mRVG\u20109R complex was injected into the cerebral cortex, striatum and hippocampus of C57BL\/6 mice by stereotactic surgery. After 2, 4, and 20 days, the animals were sacrificed and their brains were prepared for quantitative reverse\u2010transcription polymerase chain reaction and histological analysis. We detected the <jats:italic>GFP<\/jats:italic> expression in neurons and glial cells in the cerebral cortex, striatum, and hippocampus of the murine brain. The results suggest that the mRVG\u20109R peptide has the ability to deliver DNA molecules to murine brain cells. Also, the expression of the reporter gene is maintained at least up to 20 days after injection in neurons, astrocytes, oligodendrocytes, and microglia cells. Thus, the in vivo transfection ability of the mRVG\u20109R peptide, makes it a promising candidate as a therapeutic gene delivery vector to the central nervous system cells.<\/jats:p>","DOI":"10.1002\/cbin.11161","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T10:30:16Z","timestamp":1556879416000},"page":"809-819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The mRVG\u20109R peptide as a potential therapeutic vector to the central nervous system cells"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8983-3620","authenticated-orcid":false,"given":"Sheila A","family":"Villa\u2010Cedillo","sequence":"first","affiliation":[{"name":"Departamento de Histolog\u00eda, Facultad de Medicina Universidad Aut\u00f3noma de Nuevo Le\u00f3n Monterrey 64460 Nuevo Le\u00f3n 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