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Importantly, hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) has been revealed to participate in the progression of fatty liver; however, the underlying mechanism has not been clearly elucidated yet. In this study, we aimed to investigate the effects of exogenous H<jats:sub>2<\/jats:sub>S on fatty liver ischemia\u2013reperfusion injury (IRI) through mediating class A scavenger receptor (SRA) pathway in rats. By determining endoplasmic reticulum stress (ERS)\u2010related factors, autophagy markers and apoptosis\u2010related factors in liver tissue and liver function, levels of oxidative stress, inflammatory factors, and hepatocyte apoptosis, the effects of H<jats:sub>2<\/jats:sub>S on IRI\u2010induced autophagy, oxidative stress, and inflammation were all examined in rat model of fatty liver IRI. Results from obtained data showed that H<jats:sub>2<\/jats:sub>S decreased the expression of SRA, Grp78, PERK, CHOP, and Caspase\u20103, and increased that of LC3\u2010II\/LC3\u2010I, in addition to alleviating the pathological changes of liver and reducing the levels of ALT, AST, LDH TBARS, and MDA. Moreover, H<jats:sub>2<\/jats:sub>S decreased the levels of oxidative stress, the expression of pro\u2010inflammatory factors including tumor necrosis factor \u03b1, interleukin 1, and interleukin 6, and the apoptosis of hepatocytes. Our findings suggested exogenous H<jats:sub>2<\/jats:sub>S could reduce ERS by mediating the SRA pathway and protect liver function by inducing autophagy, and protect against IRI by reducing oxidative stress and inflammation.<\/jats:p>","DOI":"10.1002\/cbin.11234","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T14:27:43Z","timestamp":1567607263000},"page":"306-316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Exogenous hydrogen sulfide protects fatty liver against ischemia\u2013reperfusion injury by regulating endoplasmic reticulum stress\u2010induced autophagy in macrophage through mediating the class A scavenger receptor pathway in rats"],"prefix":"10.1002","volume":"44","author":[{"given":"Zhiyan","family":"Ruan","sequence":"first","affiliation":[{"name":"School of Pharmacy Guangdong Food &amp; Drug Vocational College  Guangzhou 510520 P.R. 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