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G\u00f66983 is a broad spectrum protein kinase C inhibitor. In this study, based on our finding that the G\u00f66983 inhibits osteolysis, we applied G\u00f66983 to the MDA\u2010MB\u2010231 breast cancer\u2010induced mouse bone metastasis model. And we found that G\u00f66983 has a strong inhibitory effect on the tumorigenic model of breast cancer by promoting the mitochondrial apoptosis pathway. 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