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Long noncoding RNA small nucleolar RNA host gene 1 (SNHG1) was reported to inhibit cardiomyocytes apoptosis, but the role and underlying mechanism of SNHG1 in pathological cardiac hypertrophy have not yet been understood. This study was designed to investigate the role and molecular mechanism of SNHG1 in regulating cardiac hypertrophy. We found that SNHG1 was upregulated during cardiac hypertrophy both in vivo (transverse aortic constriction treatment) and in vitro (phenylephrine [PE] treatment). SNHG1 overexpression attenuated the cardiomyocytes hypertrophy induced by PE, while SNHG1 inhibition promoted hypertrophic response of cardiomyocytes. Furthermore, SNHG1 and high\u2010mobility group AT\u2010hook 1 (HMGA1) were confirmed to be targets of miR\u201015a\u20105p. SNHG1 promoted HMGA1 expression by sponging miR\u201015a\u20105p, eventually attenuating cardiomyocytes hypertrophy. There data revealed a novel protective mechanism of SNHG1 in cardiomyocytes hypertrophy. Thus, targeting of SNHG1\u2010related pathway may be therapeutically harnessed to treat cardiac hypertrophy.<\/jats:p>","DOI":"10.1002\/cbin.11298","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T06:25:05Z","timestamp":1577773505000},"page":"1009-1019","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["LncRNA SNHG1 exerts a protective role in cardiomyocytes hypertrophy via targeting miR\u201015a\u20105p\/HMGA1 axis"],"prefix":"10.1002","volume":"44","author":[{"given":"Si\u2010Min","family":"Yan","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacy, Department of Pharmacy Drum Tower Hospital Affiliated to Medical School of Nanjing University  321 Zhong Shan Road Nanjing Jiangsu 210000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Drum Tower 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