{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:07:45Z","timestamp":1772914065041,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T00:00:00Z","timestamp":1598054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since its eruption in China, novel coronavirus disease (COVID\u201019) has been reported in most of the countries and territories (&gt;200) of the world with \u223c18 million confirmed cases (as of August 3, 2020). In most of the countries, COVID\u201019 upsurge is uncontrolled with a significant mortality rate. Currently, no treatment effective for COVID\u201019 is available in the form of vaccines or antiviral drugs and patients are currently treated symptomatically. Although the majority of the patients develop mild symptoms and recover without mechanical ventilation for respiratory management, severe respiratory illness develops in a significant portion of affected patients and may result in death. While the scientific community is working to develop vaccines and drugs against the COVID\u201019 pandemic, novel alternative therapies may reduce the mortality rate. Recent use of stem cells for critically ill COVID\u201019 patients in a small group of patients in China and subsequent Emergency Use Authorization of stem cells by Food and Drug Administration to Global Institute of Stem Cell Therapy and Research and Athersys has created excitement among the medical community. As a result, several clinical trials have been registered using stem cells for COVID\u201019 treatment that aim to use different cell sources, dosage, and importantly diverse targeted patient groups. In this brief review, the possibilities of stem cell use in COVID\u201019 patients and relevant challenges in their use have been discussed.<\/jats:p>","DOI":"10.1002\/cbin.11440","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T23:53:17Z","timestamp":1596844397000},"page":"2182-2191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Stem cell therapy for COVID\u201019: Possibilities and challenges"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2038-4817","authenticated-orcid":false,"given":"Mahmood S.","family":"Choudhery","sequence":"first","affiliation":[{"name":"Tissue Engineering and Regenerative Medicine Laboratory, Department of Biomedical Sciences King Edward Medical University  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Immunobiology The University of Arizona Tucson Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1559"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.09.003"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601911113"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp857"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-12-8"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe2020388"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2657"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-020-09973-w"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1570"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4236973"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_12_14_1","unstructured":"ISSCR(2020). 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