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The mortality of HVOD patients with multiorgan dysfunction is as high as 80%. The primary aim of this study was to evaluate whether the infusion of human umbilical cord\u2010derived endothelial colony forming cells (hUC\u2010ECFCs) could mitigate HVOD injury and investigate the underlying mechanism. We found that the expression of chemokine C\u2013X\u2013C chemokine ligand 12 (CXCL12) was markedly increased in the livers of HVOD mice. Meanwhile, hUC\u2010ECFCs infusion could significantly ameliorate liver injury in HVOD mice, which was accompanied by hUC\u2010ECFCs recruitment in the liver, reduced liver pathological alterations, and decreased serum alanine aminotransferase and aspartate aminotransferase activity. Besides, CXCL12\u2010induced migration in hUC\u2010ECFCs was partly impeded by chemokine receptor type 7 (CXCR7) silence or CXCR4 blockage. In conclusion, our results demonstrated that hUC\u2010ECFCs could mitigate HVOD through homing to the injured liver via the CXCL12\u2010CXCR4\/CXCR7 signaling pathway.<\/jats:p>","DOI":"10.1002\/cbin.11461","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T16:15:07Z","timestamp":1599063307000},"page":"2541-2552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The protective effects of umbilical cord\u2010derived endothelial colony forming cells on hepatic veno\u2010occlusive disease"],"prefix":"10.1002","volume":"44","author":[{"given":"Lulu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Graduate School Jining Medical University  Jining Shandong China"},{"name":"Department of Hematology Affiliated Hospital of Jining Medical University  Jining Shandong China"},{"name":"Institute of Blood and Marrow Transplantation Jining Medical University  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Jining Medical University  Jining Shandong China"},{"name":"Institute of Blood and Marrow Transplantation Jining Medical University  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Graduate School Jining Medical University  Jining Shandong China"},{"name":"Department of Hematology Affiliated Hospital of Jining Medical University  Jining Shandong China"},{"name":"Institute of Blood and Marrow Transplantation Jining Medical University  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingkang","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Graduate School Jining Medical University  Jining Shandong China"},{"name":"Department of Hematology Affiliated Hospital of Jining Medical University  Jining Shandong China"},{"name":"Institute of Blood and Marrow Transplantation Jining Medical University  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1925-6618","authenticated-orcid":false,"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Graduate School Jining Medical University  Jining Shandong China"},{"name":"Department of Hematology Affiliated Hospital of Jining Medical University  Jining Shandong China"},{"name":"Institute of Blood and Marrow Transplantation Jining Medical University  Jining Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2017-0248"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.11.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1182\/blood-2016-02-694943","article-title":"Long\u2010awaited news for hepatic veno\u2010occlusive disease","volume":"127","author":"Arai S.","year":"2016","journal-title":"Blood"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508234200"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.11.3005.bloodjournal85113005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041402"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16813"},{"key":"e_1_2_10_9_1","first-page":"1739","article-title":"Function of Kr\u00fcppel\u2010like factor 2 in the shear stress\u2010induced cell differentiation of endothelial progenitor cells to endothelial cells","volume":"19","author":"Chu H. 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