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Some genes and proteins of dermal mesenchymal stem cells (DMSCs) from psoriasis are abnormal and related to the function of endothelial cells (ECs). The present study was aimed to evaluate whether psoriatic DMSCs could affect adhesion and migration of ECs through neovascularization\u2010related integrins in psoriasis. Human DMSCs, collected from psoriasis lesions and healthy skin, respectively, were cocultured with human umbilical vein endothelial cells (HUVECs). The expression levels of three integrins, that is, \u03b1v\u03b23, \u03b1v\u03b25, and \u03b15\u03b21 in HUVECs were tested by quantitative real\u2010time polymerase chain reaction and Western blot analysis. The adhesion and migration of HUVECs were detected by adhesion assay and migration assay. The results showed that in psoriasis group, the expression of \u03b1V\u03b23 and \u03b15\u03b21 of HUVECs markedly increased 2.50\u2010 and 3.71\u2010fold in messenger RNA levels, and significantly increased 1.63\u2010 and 1.92\u2010fold in protein levels, comparing to healthy control group (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). But \u03b25 was not significantly different between the two groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05). In addition, compared with control, psoriatic DMSCs promoted HUVECs adhesion by 1.62\u2010fold and migration by 2.91\u2010fold (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). In conclusion, psoriatic DMSCs impact HUVECs adhesion and migration by upregulating the expression of integrins \u03b1V\u03b23 and \u03b15\u03b21.<\/jats:p>","DOI":"10.1002\/cbin.11492","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T15:13:16Z","timestamp":1603206796000},"page":"358-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dermal mesenchymal stem cells promoted adhesion and migration of endothelial cells by integrin in psoriasis"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7101-6948","authenticated-orcid":false,"given":"Qixin","family":"Han","sequence":"first","affiliation":[{"name":"Dermatology Department The First Hospital of China Medical University  Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuping","family":"Niu","sequence":"additional","affiliation":[{"name":"Shanxi Key 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