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Monocyte differentiation into macrophages or dendritic cells (DCs) with specific phenotypes is deeply affected by tumor signals and understanding this context is paramount to prevent and propose new therapeutic possibilities. Hence, we developed a study to better describe the modulatory effects of leukemia and lymphoma cell products on human monocytes and monocyte\u2010derived DCs secretion of cytokines such as interleukin (IL)\u20101\u03b2, tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), IL\u20106, and IL\u201012. Except with the promyelocytic leukemia cell supernatants (HL\u201060), the other two tumor supernatants (chronic myeloid leukemia, K562 and Burkitt lymphoma, DAUDI) increased both TNF\u2010\u03b1 and IL\u20101\u03b2 production by monocytes and monocytes undergoing differentiation. This effect was neither explained by alterations of cell number in culture nor by the high amount of vascular endothelial growth factor (VEGF) present in the tumor supernatants. Moreover, all supernatants used were able to induce drastic reduction of IL\u201012 secretion by cells induced to activation, suggesting a negative interference with Th1 antitumoral responses that should be a huge advantage for tumor progression.<\/jats:p>","DOI":"10.1002\/cbin.11514","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T14:38:09Z","timestamp":1606919889000},"page":"890-897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modulation of cytokine production by monocytes and developing\u2010dendritic cells under the influence of leukemia and lymphoma cell products"],"prefix":"10.1002","volume":"45","author":[{"given":"Juliana Maria","family":"Motta","sequence":"first","affiliation":[{"name":"Instituto de Bioqu\u00edmica M\u00e9dica Leopoldo de Meis Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian Mary","family":"Rumjanek","sequence":"additional","affiliation":[{"name":"Instituto de Bioqu\u00edmica M\u00e9dica Leopoldo de Meis Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-004-0551-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(10)70021-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03853.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.4.869"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-017-8944-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1096-1096"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-185686"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2004.06.028"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13933"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-3962"},{"issue":"3","key":"e_1_2_9_12_1","first-page":"180","article-title":"Forcing tumor cells to present their own tumor antigens to the immune system: A necessary design for an efficient tumor immunotherapy","volume":"1","author":"Humphreys R. 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